Proteomic and Functional Genomic Landscape of Receptor Tyrosine Kinase and Ras to Extracellular Signal–Regulated Kinase Signaling

Science Signaling - Tập 4 Số 196 - 2011
Adam A. Friedman1,2,3, George Tucker4, Rohit Singh4, Dong Yan1,3, Arunachalam Vinayagam1,3, Yanhui Hu1,3, Richard Binari1,3, Pengyu Hong5, Xiaoyun Sun5, Maura Porto1,3, Svetlana Pacifico6, Thilakam Murali6, Russell L. Finley6, John M. Asara7,8, Bonnie Berger4,9, Norbert Perrimon1,3
1Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
2Harvard–MIT Division of Health Sciences and Technology, Boston, MA 02115, USA.
3Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
4Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
5Department of Computer Science, Volen Center for Complex Systems, Brandeis University, Waltham, MA 02454, USA.
6Center for Molecular Medicine and Genetics and Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, 540 East Canfield Avenue, Detroit, MI 48201, USA.
7Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
8Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, MA 02115 USA
9Department of Mathematics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA

Tóm tắt

Interactome mapping and functional genomics in Drosophila reveal common and specific components of a mitogen-activated protein kinase pathway.

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Tập 4 Số 196

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