Tác dụng bảo vệ của Amtolmetin Guacyl so với placebo Diclofenac và Misoprostol trên các tình nguyện viên khỏe mạnh được đánh giá qua hoạt động điện sinh học của dạ dày trong tổn thương dạ dày do rượu
Tóm tắt
Từ khóa
#Amtolmetin Guacyl #thuốc chống viêm không steroid #rối loạn nhịp dạ dày #tổn thương dạ dày do rượu #tình nguyện viên khỏe mạnhTài liệu tham khảo
Takeuchi K, Ueki S, Okabe S: Importance of gastric motility in the pathogenesis of indomethacin-induced gastric lesions in rats. Dig Dis Sci 31:1114–1121, 1986
Whittle BJR: Temporal relationship between cyclooxigenase inhibition, as measured by prostacyclin biosynthesis, and the gastrointestinal damage induced by indomethacin in the rat. Gastoenterology 80:94–98, 1981
Wallace JL, Keeman CM, Granger DN: Gastric ulceration induced by nonsteroidal anti-inflammatory drugs is a neutrophil-dependent process. Am J Physiol 259:G461–G467, 1990
Takeuchi K, Ueshima K, Hironaka Y, Fujioka Y, Matsumotob J, Okabe S: Oxygen free radicals and lipid peroxidation in the pathogenesis of gastric mucosal lesions induced by indomethacin in rats. Digestion 49:175–184, 1991
Okada M, Niida H, Kakeuki K, Okabe S: Role of prostaglandin deficiency in pathogenetic mechanism of gastric lesions induced by indometacin in rats. Dig Dis Sci 34:694–702, 1989
Takeuchi K, Kato S, Takuya H, and Nishiwaki H: Gastric motility and mucosal ulcerogenic responses induced by prokinetic drugs in rats under prostaglandin-deficient conditions. Dig Dis Sci 42:251–258, 1997
Tubaro E, Belogi L, Mezzadri CM, Ruco L, Stoppacciaro A: Studies on the gastric tolerability of the new non-steroidal anti-inflammatory drug amtolmetin guacyl. Arzneim Forsch Drug Res 45:1298–1302, 1995
Tubaro E., Belogi L., Mezzadri C. M. The mechanism of action of amtolmetin guacyl, a new gastroprotective non-steroidal anti-inflammatory drug. Eur J Pharmacol 387:233–244, 2000
Pisano C, Grandi D, Morini G, Coppelli G, Vesci L, Lo Giudice P, Pace S, Pacifici L, Longo A, Coruzzi G, Carminati P: Gastrosparing effect of new antiinflammatory drug amtolmetin guacyl in the rat. Involvement of nitric oxide. Dig Dis Sci 44:713–724, 1999
Takeuchi K, Niida H, Matsumoto J, Ueshima K, Okabe S: Gastric motility changes in capsaicin-induced cytoprotection in the rat stomach. Jpn J Pharmacol 55:147–155, 1991
Stern AI, Hogan DL, Isenberg JI: A new method for quantitation of ion fluxes across in vivo human gastric mucosa. Effect of aspirin, acetaminophen, ethanol, and hyperosmolar solutions. Gastroenterology 186:60–64, 1984
Bode C, Ganzhorn A, Brauner B, Bode JC: Effect of acute ethanol ingestion on human gastric luminal prostaglandin E2, prostaglandin F2 alpha and 6-keto-prostaglandin F1 alpha. Alcohol Alcohol 24:35–42, 1989
Barboriak JJ, Meade RC: Effect of alcohol on gastric emptying in man. Am J Clin Nutr 23:1151, 1970
Crean GP, Card WI, Beattie AD, et al: Ulcer-like dyspepsia. Scand J Gastroenterol 17(suppl 79):9–15, 1982
Moore JG, Christian PE, Datz FL, Coleman RE: Effect of wine on gastric emptying in humans. Gastroenterology 81:1072–1075, 1981
Szurszewski JH: Electrical basis for gastrointestinal motility. In LR Johnson (ed). Physiology of the Gastrointestinal tract, Vol 2. New York, Raven Press, 1981, pp 1435–1466.
Chen JZ, McCallum RW: Electrogastrography: Principles and Applications. New York, Raven Press, 1994
Chen J, Schirmer BD, McCallum RW: Frequency components of the electrogastrogram and their correlations with gastrointestinal motility. Med Biol Eng Comput 31:60–67, 1993
Code CF, Marlett JA: Modern medical physiology: canine tachygastria. Mayo Clin Proc 49:325–332, 1974
Telander RL, Morgan KG, Kreulen DL, Schemalz PF, Kelly KA Szurszewsky JH: Human gastric atony with tachygastria and gastric retention. Gastroenterology 75:495–501, 1978
Yiu CH, Chey WY, Lee KY, et al: Gastric and small intestinal myoelectrical dysrhythmias associated with chronic intractable nausea and vomiting. Ann Intern Med 95:449–451, 1981
Geldof H, Van der Schee EJ, Smouth AJPM: Myoelectrical activity of the stomach in gastric ulcer patients: An electrogastrographic study. J Gastrointestinal Motil 1:122–130, 1989
Giorgio I, Lemaire MC, Pezzolla F, Abbattista N, Thouvenot J: Caractéristiques spectrales de l'électrogastrogramme dans le cancer gastrique. Possibilités de depistage. Pathol Biol 36:1211–1216, 1988
Giorgio I, Abbattista N, Lemaire MC, Pezzolla F, Thouvenot J: La composante spectrale de l'électrogastrogramme (EGG): Ses facteurs de variations chez le sujet normal, cancéreux et ulcereux. Pathol Biol 37:712–719, 1989
Geldof H, van der Schee EJ, Smout AJPM, van de Merwe JP, van Blankenstein M, Grashuis JL: Myoelectrical activity of the stomach in gastri ulcer patients: An electrogastrographic study. J Gastrointes Motil 1:122–130, 1989
Kamiya T, Nagao T, Andou T, Misu N, Kobayashi Y, Hirako M, Hara M, Fujinami T: Effect of trimebutine maleate on gastric motility in patients with gastric ulcer. J Gastroenterol 33:823–827, 1998
Van der Schee EJ, Smout AJPM, Grashuis JL: Application of running spectrum analysis to electrogastrographic signals recorded from dog and man. In Motility of the Digestive Tract. M Wenbeck, (ed.). New York, Raven Press, 1982, pp 241–250
Bolondi L, Gaiani S, Barbara L: Ecografia funzionale ed ecodoppler in gastroenterologia Milan, Masson, 1989
Bolondi L, Bortolotti M, Santi V, et al: Measurement of gastric emptying time by real time ultrasonography. Gastroenterology 89:752–759, 1985
Bolondi L, Santi V, Bortolotti M, Li Bassi S, Turba E: Correlation between scintigraphic and ultrasonographic assessment of gastric emptying. Gastroenterology 90:1349, 1986
Wolfe MM, Lichtenstein DR, Singh G: Gastrointestinal toxicity of nonsteroidal antiinflammatory drugs. N Engl J Med 340:1888–1899, 1999
Barboriak JJ, Meade RC: Effect of alcohol on gastric emptying in man. Am J Clin Nutr 23:1151, 1970
Cortot A, Jobin G, Duerort F, Giradeaux V, Modigliani R: Gastric emptying and gastrointestinal absorption of alcohol ingested with a meal. Dig Dis Sci 31:343–348, 1986
Tarnawski A, Hollander D, Stachura J, Klimczyk B, Mach T, Bogdal J: Alcohol injury to the normal human gastric mucosa: Endoscopic, histologic and functional assessment. Clin Invest Med 10:259–263, 1987
Crean GP, Card WI, Beattie AD, et al: Ulcer-like dyspepsia. Scand J Gastroenterol 17(Suppl 79):9–15, 1982
Kim MS, Lee YL, Jo YH, Sim SS, Choi H: Effect of prostaglandin E2 on the electrical activity of the cat isolated stomach muscle. Prostaglandins 30:99–107, 1985
Kim CH, Zinsmeister AR, Malagelada JR: Effect of gastric dysrhythmias on postcibal motor activity of the stomach. Dig Dis Sci 33:193–199, 1988
Kohagen KR, Kim MS, McDonnell WM, Chey WD, Owyang C, Hasler WL: Nicotine ceffects on prostaglandin dependent gastric slow wave rhythmicity and antral motility in nonsmokers and smokers. Gastroenterology 1:3–11, 1996
Munt PL, Williams C: MED15 (amtolmetin guacyl). Effect on gastric acid secretion in the anaesthetized rat (response to peptone and CGRP8-37). Huntington Life Science, UK, 1996
Lamrecht N, Burchert M, Respondek M, Muller KM, Peskar BM: Role of calcitonin gene-related peptide and nitric oxide in the gastroprotective effect of capsaicin in the rat. Gastroenterology 104:1371–1380, 1993
Maton PN, Sutliff VE, Zhou Z-C, Colins SM, Gardner JD, Jensen RT: Characterization of receptors for calcitonin generelated-peptide on gastric smooth muscle. Am J Physiol 254:G789–G794, 1988
Chijiwa Y, Kabemura T, Misawa T, Kawakami O, Nawata H: Direct inhibitory effect of calcitonin gene-related-peptideand atrial natriutetic peptided on gastric smooth muscle via different mechanisms. Life Sci 50:1615–1623, 1992
Tache Y, Raybould H, Wei JY: Central and peripheral actions of calcitonin gene related peptide on the gastric secretory and motor funtion. Adv Exp Med Biol 298:193–198, 1991