Protease‐activated receptor 2 contributes to Toxoplasma gondii‐mediated gut inflammation

Parasite Immunology - Tập 39 Số 11 - 2017
Chrystelle Bonnart1, Guylène Feuillet1, Virginie Vasseur2, Nicolas Cénac1, Nathalie Vergnolle1, Nicolas Blanchard2
1Institut de Recherche en Santé Digestive (IRSD) Université de Toulouse INSERM, INRA, ENVT, UPS Toulouse France
2Centre de Physiopathologie de Toulouse Purpan (CPTP) Université de Toulouse INSERM, CNRS, UPS Toulouse France

Tóm tắt

SummaryToxoplasma gondii is a widespread intracellular parasite, which naturally enters the organism via the oral route and crosses the intestinal barrier to disseminate. In addition to neuronal and ocular pathologies, this pathogen also causes gut inflammation in a number of animals. This infection‐triggered inflammation has been extensively studied in the C57BL/6 mice, highlighting the importance of the immune cells and their mediators in the development of gut pathology. However, despite their importance in inflammation, the role of protease‐activated receptors (PAR) was never reported in the context of T.gondii‐mediated small intestine inflammation. Using genetically modified mice, we show that PAR2 plays a pathogenic role in the development of gut inflammatory lesions. We find that PAR2 controls the innate inflammatory mediators IL‐6, KC/CXCL1, PGE2 as well as neutrophil infiltration in T. gondii‐triggered gut damage. These results bring new knowledge on the mechanisms operating in the gut in response to T. gondii infection.

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Parasite Immunology

Tập 39 Số 11

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