Prostate‐specific antigen and prostate gland volume: Correlation and clinical application

Journal of Clinical Laboratory Analysis - Tập 4 Số 2 - Trang 135-137 - 1990
R. Joseph Babaian1, Robert B. Evans1, Herbert A. Fritsche2
1Department of Urology, University of Texas M. D. Anderson Cancer Center, Houston, Texas
2Department of Laboratory Medicine, University of Texas M. D. Anderson Cancer Center, Houston, Texas

Tóm tắt

AbstractWe studied 103 patients seen in our Prostate Cancer Detection Clinic to determine whether a correlation exists between serum prostate‐specific antigen (PSA) values and ultrasound‐calculated prostate gland volume. Seventy men (68%) had a PSA value ≤ ng/ml (our upper limit of normal). The men were subclassified by prostate gland volume at arbitrary break points. Twenty‐five men (24%) had a prostate gland volume ≤ 25 cm3; in 96%, the PSA value was ≤ 4 mg/ml. Further analysis revealed that the percentage of men with a normal serum PSA value decreased as the prostate gland volume increased; 65.6% of the group with a gland volume between 25 and 50 cm3 (40 of 61) and 35.5% of the group whose prostate volume exceeded 50 cm3 (6 of 17) had PSA values ≤4 ng/ml. Four men had PSA values ≥20 ng/ml; all had prostate cancer. Cancer was diagnosed in four additional patients, three with PSA values between 5 and 10 ng/ml and one with a PSA value <4 ng/ml. There appears to be a direct relationship between prostate gland volume and PSA value, as well as a cancer value threshold. The clinical implications of these findings are discussed.

Từ khóa


Tài liệu tham khảo

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Thông tin
Thông tin xuất bản

Journal of Clinical Laboratory Analysis

Tập 4 Số 2

135-137

Thông tin tác giả