Prospective representation of navigational goals in the human hippocampus

American Association for the Advancement of Science (AAAS) - Tập 352 Số 6291 - Trang 1323-1326 - 2016
Thackery I. Brown1, Valerie A. Carr2,1, Karen F. LaRocque1, Serra E. Favila3, Alan Gordon1, Ben Bowles4, Jeremy N. Bailenson5, Anthony D. Wagner1,6
1Department of Psychology, Stanford University, Stanford, CA, USA
2Department of Psychology, San Jose State University, San Jose, CA USA
3Department of Psychology, New York University, New York, NY, USA
4Department of Psychology, University of California – Berkeley, Berkeley, CA, USA
5Department of Communication, Stanford University, Stanford, CA, USA.
6Neurosciences Program, Stanford University, Stanford, CA, USA

Tóm tắt

Brain activity to represent the future How do humans navigate from A to B? Brown et al. developed a virtual reality task to investigate the neural representations that support human navigational planning. Highly specific activity of the hippocampus and related brain areas represented the future locations to which participants eventually moved. Network-level interactions of the hippocampus with the prefrontal cortex thus enable flexible representation of planned destinations. Science , this issue p. 1323

Từ khóa


Tài liệu tham khảo

10.1098/rstb.2008.0308

10.1016/j.tics.2006.11.004

10.1016/S0896-6273(00)00071-4

10.1016/j.neuron.2006.06.033

10.1523/JNEUROSCI.3234-05.2006

10.1038/nature14396

10.1016/S0896-6273(03)00752-9

10.1002/hipo.22273

10.1093/cercor/bht041

10.1523/JNEUROSCI.6021-09.2010

10.1016/j.neuroimage.2012.01.046

10.1523/JNEUROSCI.2202-13.2014

10.1016/j.neunet.2005.08.007

10.1016/j.nlm.2009.07.005

10.1016/j.neuroimage.2013.06.022

10.1523/JNEUROSCI.3761-07.2007

10.1038/nn.3909

10.1016/j.neuropsychologia.2006.10.016

10.1016/j.neuron.2010.06.023

10.1037/0033-295X.114.2.340

10.1098/rstb.2001.0948

10.1038/nrn1343

10.3389/fnhum.2015.00125

10.1126/science.1244056

10.1038/nature01964

10.1016/j.cub.2014.05.001

10.1523/JNEUROSCI.1825-13.2013

10.1002/hipo.20298

10.1038/nature08704

10.1016/j.cub.2014.11.001

10.3389/fnhum.2014.00716

10.1016/j.cub.2009.02.033

10.1038/nn.3834

10.1523/JNEUROSCI.2270-15.2015

10.1523/JNEUROSCI.0879-13.2013

10.1093/cercor/bhr379

10.1016/j.tics.2013.06.009

10.1523/JNEUROSCI.3891-12.2013

10.1002/hipo.450050604

10.3389/fnhum.2014.00571

10.1371/journal.pone.0015710

10.1002/mrm.23097

10.1006/nimg.2001.0746

InsaustiR.JuottonenK.SoininenH.InsaustiA. M.PartanenK.VainioP.LaaksoM. P.PitkänenA., MR volumetric analysis of the human entorhinal, perirhinal, and temporopolar cortices. AJNR Am. J. Neuroradiol. 19, 659–671 (1998).9576651

10.1093/cercor/10.4.433

10.1093/cercor/12.12.1342

10.1006/nimg.2000.0561

H. M. Duvernoy The Human Hippocampus: Functional Anatomy Vascularization and Serial Sections with MRI (Springer 2005).

10.1162/jocn.2009.21195

10.1016/S0896-6273(00)80374-8

10.1016/j.neuroimage.2007.07.007

SharpP. E.GreenC., Spatial correlates of firing patterns of single cells in the subiculum of the freely moving rat. J. Neurosci. 14, 2339–2356 (1994).8158272

10.1002/(SICI)1098-1063(1996)6:6<749::AID-HIPO16>3.0.CO;2-0

10.1073/pnas.0600244103

RodriguezP. F., Neural decoding of goal locations in spatial navigation in humans with fMRI. Hum. Brain Mapp. 31, 391–397 (2010).19722170

10.1006/nimg.2001.0978

10.1016/j.neuroimage.2003.09.032

10.1016/S1053-8119(03)00169-1