Proprotein convertase subtilisin/kexin type 9 (PCSK9): Hepatocyte-specific low-density lipoprotein receptor degradation and critical role in mouse liver regeneration

Seidah, 2003, The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation, Proc Natl Acad Sci U S A, 100, 928, 10.1073/pnas.0335507100

Seidah, 2007, The proprotein convertases are potential targets in the treatment of dyslipidemia, J Mol Med, 85, 685, 10.1007/s00109-007-0172-7

Seidah, 1999, Mammalian subtilisin/kexin isozyme SKI-1: a widely expressed proprotein convertase with a unique cleavage specificity and cellular localization, Proc Natl Acad Sci U S A, 96, 1321, 10.1073/pnas.96.4.1321

Sakai, 1998, Cleavage of sterol regulatory element-binding proteins (SREBPs) at site- 1 requires interaction with SREBP cleavage-activating protein. Evidence from in vivo competition studies, J Biol Chem, 273, 5785, 10.1074/jbc.273.10.5785

Brown, 2000, Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans, Cell, 100, 391, 10.1016/S0092-8674(00)80675-3

Jin, 2005, Proprotein convertases are responsible for proteolysis and inactivation of endothelial lipase, J Biol Chem, 280, 36551, 10.1074/jbc.M502264200

Benjannet, 2006, The proprotein convertase PCSK9 is inactivated by furin and/or PC5/6A: functional consequences of natural mutations and post-translational modifications, J Biol Chem, 281, 30561, 10.1074/jbc.M606495200

Cunningham, 2007, Structural and biophysical studies of PCSK9 and its mutants linked to familial hypercholesterolemia, Nat Struct Mol Biol, 14, 413, 10.1038/nsmb1235

Zhang, 2007, Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat a of low density lipoprotein receptor decreases receptor recycling and increases degradation, J Biol Chem, 282, 18602, 10.1074/jbc.M702027200

Kwon, 2008, Molecular basis for LDL receptor recognition by PCSK9, Proc Natl Acad Sci U S A, 105, 1820, 10.1073/pnas.0712064105

Maxwell, 2004, Adenoviral-mediated expression of Pcsk9 in mice results in a low-density lipoprotein receptor knockout phenotype, Proc Natl Acad Sci U S A, 101, 7100, 10.1073/pnas.0402133101

Benjannet, 2004, NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol, J Biol Chem, 279, 48865, 10.1074/jbc.M409699200

Nassoury, 2007, The cellular trafficking of the secretory proprotein convertase PCSK9 and its dependence on the LDLR, Traffic, 8, 718, 10.1111/j.1600-0854.2007.00562.x

Poirier, 2006, Implication of the proprotein convertase NARC-1/PCSK9 in the development of the nervous system, J Neurochem, 98, 838, 10.1111/j.1471-4159.2006.03928.x

Abifadel, 2003, Mutations in PCSK9 cause autosomal dominant hypercholesterolemia, Nat Genet, 34, 154, 10.1038/ng1161

Timms, 2004, A mutation in PCSK9 causing autosomal-dominant hypercholesterolemia in a Utah pedigree, Hum Genet, 114, 349, 10.1007/s00439-003-1071-9

Cohen, 2005, Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9, Nat Genet, 37, 161, 10.1038/ng1509

Rashid, 2005, Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9, Proc Natl Acad Sci U S A, 102, 5374, 10.1073/pnas.0501652102

Zhao, 2006, Molecular characterization of loss-of-function mutations in PCSK9 and identification of a compound heterozygote, Am J Hum Genet, 79, 514, 10.1086/507488

Hooper, 2007, The C679X mutation in PCSK9 is present and lowers blood cholesterol in a Southern African population, Atherosclerosis, 193, 445, 10.1016/j.atherosclerosis.2006.08.039

Lagace, 2006, Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and inlivers of parabiotic mice, J Clin Invest, 116, 2995, 10.1172/JCI29383

DeAngelis, 2005, A high-fat diet impairs liver regeneration in C57BL/6 mice through overexpression of the NF-kappaB inhibitor, IkappaBalpha, HEPATOLOGY, 42, 1148, 10.1002/hep.20879

Dietschy, 1993, Role of liver in the maintenance of cholesterol and low density lipoprotein homeostasis in different animal species, including humans, J Lipid Res, 34, 1637, 10.1016/S0022-2275(20)35728-X

Qian, 2007, Secreted PCSK9 downregulates low density lipoprotein receptor through receptor-mediated endocytosis, J Lipid Res, 48, 1488, 10.1194/jlr.M700071-JLR200

Giovannini, 2003, Characterization of biochemical and clinical correlates of hypocholesterolemia after hepatectomy, Clin Chem, 49, 317, 10.1373/49.2.317

Poirier, 2008, The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor LDLR and its closest family members VLDLR and APOER2, J Biol Chem, 283, 2363, 10.1074/jbc.M708098200

Park, 2004, Post-transcriptional regulation of low density lipoprotein receptor protein by proprotein convertase subtilisin/kexin type 9a in mouse liver, J Biol Chem, 279, 50630, 10.1074/jbc.M410077200

Brown, 2006, Biomedicine. Lowering LDL-not only how low, but how long?, Science, 311, 1721, 10.1126/science.1125884

Cho, 2006, Mild hepatic steatosis is not a major risk factor for hepatectomy and regenerative power is not impaired, Surgery, 139, 508, 10.1016/j.surg.2005.09.007