Prophylactic fresh frozen plasma and platelet transfusion have a prothrombotic effect in patients with liver disease

Stanworth, 2011, The use of fresh‐frozen plasma in England: high levels of inappropriate use in adults and children, Transfusion, 51, 62, 10.1111/j.1537-2995.2010.02798.x Wells, 2009, The EASTR study: indications for transfusion and estimates of transfusion recipient numbers in hospitals supplied by the National Blood Service, Transfus Med, 19, 315, 10.1111/j.1365-3148.2009.00933.x Northup, 2013, Coagulation in liver disease: a guide for the clinician, Clin Gastroenterol Hepatol, 11, 1064, 10.1016/j.cgh.2013.02.026 Lisman, 2010, Rebalanced hemostasis in patients with liver disease: evidence and clinical consequences, Blood, 116, 878, 10.1182/blood-2010-02-261891 Turon, 2013, Variceal and other portal hypertension related bleeding, Best Pract Res Clin Gastroenterol, 27, 649, 10.1016/j.bpg.2013.08.004 Schepis, 2018, Prevention and management of bleeding risk related to invasive procedures in cirrhosis, Semin Liver Dis, 38, 215, 10.1055/s-0038-1660523 Lisman, 2017, Value of preoperative hemostasis testing in patients with liver disease for perioperative hemostatic management, Anesthesiology, 126, 338, 10.1097/ALN.0000000000001467 O'Leary, 2019, AGA clinical practice update: coagulation in cirrhosis, Gastroenterology, 157, 34, 10.1053/j.gastro.2019.03.070 2016, Hemostatic balance in patients with liver cirrhosis: report of a consensus conference, Dig Liver Dis, 48, 455, 10.1016/j.dld.2016.02.008 2018, EASL clinical practice guidelines for the management of patients with decompensated cirrhosis, J Hepatol, 69, 406, 10.1016/j.jhep.2018.03.024 Triulzi, 2015, A multicenter study of plasma use in the United States, Transfusion, 55, 1313, 10.1111/trf.12970 Napolitano, 2017, Bleeding after invasive procedures is rare and unpredicted by platelet counts in cirrhotic patients with thrombocytopenia, Eur J Intern Med, 38, 79, 10.1016/j.ejim.2016.11.007 Giannini, 2010, Incidence of bleeding following invasive procedures in patients with thrombocytopenia and advanced liver disease, Clin Gastroenterol Hepatol, 8, 899, 10.1016/j.cgh.2010.06.018 Lippi, 2019, Platelet transfusion thresholds: how low can we go in respect to platelet counting?, Semin Thromb Hemost, 46, 238 Lisman, 2018, In vitro efficacy of pro‐ and anticoagulant strategies in compensated and acutely ill patients with cirrhosis, Liver Int, 38, 1988, 10.1111/liv.13882 Tripodi, 2012, Thrombin generation in plasma from patients with cirrhosis supplemented with normal plasma: considerations on the efficacy of treatment with fresh‐frozen plasma, Intern Emerg Med, 7, 139, 10.1007/s11739-011-0528-4 Rassi, 2020, Fresh frozen plasma transfusion in patients with cirrhosis and coagulopathy: effect on conventional coagulation tests and thrombomodulin‐modified thrombin generation, J Hepatol, 72, 85, 10.1016/j.jhep.2019.09.008 Tripodi, 2013, Global hemostasis tests in patients with cirrhosis before and after prophylactic platelet transfusion, Liver Int, 33, 362, 10.1111/liv.12038 De Pietri, 2016, Thrombelastography‐guided blood product use before invasive procedures in cirrhosis with severe coagulopathy: a randomized, controlled trial, Hepatology, 63, 566, 10.1002/hep.28148 Toy, 2012, Transfusion‐related acute lung injury: incidence and risk factors, Blood, 119, 1757, 10.1182/blood-2011-08-370932 Benson, 2010, Transfusion‐related acute lung injury in ICU patients admitted with gastrointestinal bleeding, Intensive Care Med, 36, 1710, 10.1007/s00134-010-1954-x Murphy, 2013, Risk factors and outcomes in transfusion‐associated circulatory overload, Am J Med, 126, 357.e29, 10.1016/j.amjmed.2012.08.019 Hemker, 2003, Calibrated automated thrombin generation measurement in clotting plasma, Pathophysiol Haemost Thromb, 33, 4, 10.1159/000071636 von Meijenfeldt, 2018, Elevated plasma levels of cell‐free DNA during liver transplantation are associated with activation of coagulation, Liver Transpl, 24, 1716, 10.1002/lt.25329 Kessenbrock, 2009, Netting neutrophils in autoimmune small‐vessel vasculitis, Nat Med, 15, 623, 10.1038/nm.1959 Intagliata, 2018, Concepts and controversies in haemostasis and thrombosis associated with liver disease: proceedings of the 7th international coagulation in liver disease conference, Thromb Haemost, 118, 1491, 10.1055/s-0038-1666861 van Veen, 2008, Thrombin generation testing in routine clinical practice: are we there yet?, Br J Haematol, 142, 889, 10.1111/j.1365-2141.2008.07267.x Rinder, 1991, Progressive platelet activation with storage: evidence for shortened survival of activated platelets after transfusion, Transfusion, 31, 409, 10.1046/j.1537-2995.1991.31591263195.x Stoy, 2018, Platelet‐leucocyte aggregation is augmented in cirrhosis and further increased by platelet transfusion, Aliment Pharmacol Ther, 47, 1375, 10.1111/apt.14600