Prolonged institutional rearing is associated with atypically large amygdala volume and difficulties in emotion regulation

Developmental Science - Tập 13 Số 1 - Trang 46-61 - 2010
Nim Tottenham1, Todd A. Hare2, Brian Quinn3, Thomas McCarry1, Marcella Nurse1, Tara Gilhooly1, Alexander J. Millner1, Adriana Gálvan4, Matthew C. Davidson5, Inge‐Marie Eigsti6, Kathleen M. Thomas7, Peter Freed8, Elizabeth S. Booma1, Megan R. Gunnar7, Margaret Altemus9, Jane Aronson10, B.J. Casey1
1Sackler Institute for Developmental Psychobiology, Weill Medical College of Cornell University, USA
2Division of the Humanities and Social Sciences, California Institute of Technology, USA
3 Department of Pedriatric Neurology, Weill Medical College of Cornell University, USA
4Department of Psychology, University of California, Los Angeles, USA
5Department of Psychology, University of Massachusetts, Amherst, USA
6Department of Psychology University of Connecticut USA
7Institute of Child Development, University of Minnesota, USA.
8Department of Psychiatry, Columbia University, USA
9Department of Psychiatry, Weill Medical College of Cornell University, USA
10 Department of Pedriatrics, Weill Medical College of Cornell University, USA

Tóm tắt

AbstractEarly adversity, for example poor caregiving, can have profound effects on emotional development. Orphanage rearing, even in the best circumstances, lies outside of the bounds of a species‐typical caregiving environment. The long‐term effects of this early adversity on the neurobiological development associated with socio‐emotional behaviors are not well understood. Seventy‐eight children, who include those who have experienced orphanage care and a comparison group, were assessed. Magnetic resonance imaging (MRI) was used to measure volumes of whole brain and limbic structures (e.g. amygdala, hippocampus). Emotion regulation was assessed with an emotional go‐nogo paradigm, and anxiety and internalizing behaviors were assessed using the Screen for Child Anxiety Related Emotional Disorders, the Child Behavior Checklist, and a structured clinical interview. Late adoption was associated with larger corrected amygdala volumes, poorer emotion regulation, and increased anxiety. Although more than 50% of the children who experienced orphanage rearing met criteria for a psychiatric disorder, with a third having an anxiety disorder, the group differences observed in amygdala volume were not driven by the presence of an anxiety disorder. The findings are consistent with previous reports describing negative effects of prolonged orphanage care on emotional behavior and with animal models that show long‐term changes in the amygdala and emotional behavior following early postnatal stress. These changes in limbic circuitry may underlie residual emotional and social problems experienced by children who have been internationally adopted.

Từ khóa


Tài liệu tham khảo

Achenbach T.M, 1991, Integrative guide to the 1991 CBCL/4‐18, YSR, and TRF profiles

Ames E., 1990, Spitz revisited: a trip to Romanian ‘orphanages’, Canadian Psychological Association Developmental Psychology Section Newsletter, 9, 8

Ames E., 1997, The development of Romanian orphan‐age children adopted to Canada (final report to the National Welfare Grants Program: Human Resources Development Canada)

Barbazanges A., 1996, Early and later adoptions have different long‐term effects on male rat offspring, Journal of Neuroscience, 16, 7783, 10.1523/JNEUROSCI.16-23-07783.1996

10.1016/j.neuroimage.2006.07.025

10.1111/j.1467-8624.2006.00898.x

10.1097/00004583-199910000-00011

10.1186/1744-9081-3-7

10.1176/appi.ajp.158.8.1248

10.1348/014466599162845

10.31887/DCNS.2006.8.4/jbremner

10.1176/ajp.152.7.973

10.1016/S0006-3223(96)00162-X

10.1176/appi.ajp.160.5.924

10.1073/pnas.95.9.5335

10.1006/nimg.2001.0917

10.1001/archpsyc.1996.01830120067012

10.1017/S0033291701003567

10.1038/sj.mp.4000812

10.1016/S0006-3223(00)00835-0

10.1016/S0006-3223(99)00045-1

10.1037/0021-843X.111.2.225

10.1111/j.1749-6632.2003.tb07093.x

Durfee H., 1933, Anstaltspflege und entwicklung im ersten lebensjahr, Zeitschrift fur Kinderforschung, 42, 273

10.1016/0191-8869(85)90026-1

10.1097/01.chi.0000136562.24085.160

10.1016/S0896-6273(02)00569-X

10.1016/j.neuroimage.2004.07.016

10.1111/j.1749-6632.1999.tb08106.x

10.1016/S0006-3223(01)01359-2

10.1002/(SICI)1096-9861(19960304)366:2<223::AID-CNE3>3.0.CO;2-7

10.2307/1130197

10.1073/pnas.82.13.4549

10.1016/0006-8993(86)91437-X

10.1017/S0954579400004077

10.1017/S0954579407070071

10.1016/S0006-3223(96)00229-6

10.1111/1469-7610.00133

10.1016/j.biopsych.2004.12.038

10.1016/j.biopsych.2008.03.015

10.1007/s10995-007-0237-9

10.1111/j.1469-7610.1989.tb00770.x

10.1097/00004583-200202000-00012

10.1007/s002130100701

10.1016/S0378-3782(02)00017-8

10.1001/jama.293.20.2501

10.1111/j.1469-7610.2006.01640.x

10.1016/S0006-3223(98)00246-7

10.1016/j.biopsych.2004.05.021

10.1196/annals.1314.001

10.1152/physrev.00041.2006

10.1089/104454603321666207

10.1073/pnas.0504011102

10.1016/S0005-7967(96)00109-X

10.1080/14640749408401099

10.1016/0005-7967(93)90107-6

10.1017/S0954579402003061

10.1126/science.1143921

10.1097/00004583-200006000-00008

Orvaschel H., 1994, Schedule for Affective Disorders and Schizophrenia for School Age Children ‐ Parent version (KSADS‐P) (5th edn.)

10.1111/j.1467-8624.2005.00829.x

10.1037/0012-1649.38.5.784

10.1111/j.1467-8624.2005.00890.x

10.1016/S0006-3223(00)00828-3

10.1037/0735-7044.110.1.43

10.1037/0033-295X.105.2.325

10.1002/dev.1026

10.1111/1469-7610.00343

10.1037/0012-1649.40.1.81

10.1016/j.bbr.2007.05.020

10.1016/S0925-4927(03)00023-4

10.1001/archpsyc.62.3.273

10.1097/00004583-200208000-00016

10.1111/j.1469-7610.2006.01694.x

10.1001/archpsyc.58.11.1057

10.1016/j.biopsych.2005.08.007

US Department of State(2008). Available online athttp://adoption.state.gov/news/total_chart.html.

10.1111/j.1469-7610.2006.01675.x

Vasey M.W., 1996, Anxiety and the processing of emotionally threatening stimuli: distinctive patterns of selective attention among high‐ and low‐test‐anxious children, Child Development, 67, 1173, 10.2307/1131886

10.1016/S0006-8993(02)04162-8

10.1016/j.neuroscience.2006.08.003

10.1523/JNEUROSCI.22-15-06810.2002

10.1016/j.neuroscience.2004.07.013

Wechsler D.(1999).The Wechsler Abbreviated Scale of Intelligence. New York:The Psychological Corproation.

10.1016/j.biopsych.2004.09.015

10.1037/0033-2909.120.1.3

10.1016/j.nlm.2006.09.001

10.1017/S0954579403000452

Thông tin
Thông tin xuất bản

Developmental Science

Tập 13 Số 1

46-61

Thông tin tác giả