Vasileios Papaliagkas1, G. Anogianakis1, Magda Tsolaki2, George Koliakos3, Vasilios Κ. Kimiskidis2
1Department of Experimental Physiology, Faculty of Medicine,
2Third Department of Neurology, G. Papanikolaou Hospital,
3Laboratory of Biological Chemistry,Faculty of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece
Tóm tắt
<i>Background/Aims:</i> The aim of this study was to investigate the role of cerebrospinal fluid β-amyloid(1–42) levels and auditory event-related potentials (AERPs) in the progress of mild cognitive impairment (MCI) to Alzheimer’s disease (AD). <i>Methods:</i> In 53 MCI patients, lumbar puncture was performed and β-amyloid(1–42) levels were determined. Twenty patients were reexamined after 11 months. During this period, 5 of them progressed to AD. Neuropsychological and ERP analyses were performed on all patients during both baseline and endpoint examinations. <i>Results:</i> Compared to stable MCI patients, those that progressed to AD had significantly lower β-amyloid(1–42) levels (Mann-Whitney test, Z = –2.952, p = 0.003; effect size r = –0.41) and significantly prolonged N200 latencies (Mann-Whitney test, Z = –3.561, p < 0.001, effect size r = –0.49). From ERP variables, only the N200 latency significantly correlated with β-amyloid(1–42) levels (baseline examination: r<sub>s</sub> = –0.421, p = 0.002; follow-up examination: r<sub>s</sub> = –0.574, p = 0.008). <i>Conclusions:</i> The combined use of these two parameters enabled discrimination of stable MCI patients from those who developed AD, with 100% sensitivity and specificity. Therefore, this method could be of high diagnostic value for the early diagnosis of AD.
