Prognostic Value of Galectin-3 in Patients with Heart Failure

Disease Markers - Tập 2015 - Trang 1-6 - 2015
Ivica Bošnjak1, Kristina Selthofer-Relatić1,2, Aleksandar Včev3,2
1Department for Cardiovascular Disease, Clinic for Internal Medicine, University Hospital Centre Osijek, J. Huttlera 4, 31000 Osijek, Croatia
2Faculty of Medicine Osijek, University Josipi Juraj Strossmayer Osijek, J. Huttlera 4, 31000 Osijek, Croatia
3Department for Gastroenterology, Clinic for Internal Medicine, University Hospital Centre Osijek, Osijek, Croatia

Tóm tắt

Galectins are a family of solubleβ-galactoside-binding lectins that have important role in inflammation, immunity, and cancer. Galectin-3 as a part of this lectin family plays a very important role in development of heart failure. According to recent papers, galectin-3 plasma level correlates with heart failure outcome, primarily with rehospitalisation and death from heart failure. This paper summarizes the most recent advances in galectin-3 research, with the accent on the role of galectin-3 in pathophysiology of myocardial remodelling and heart failure development—with preserved and reduced ejection fraction, and some implication on development of new disease modifying drugs.

Từ khóa


Tài liệu tham khảo

10.1016/j.jacc.2008.10.041

2011, Epidemiology of heart failure, 346

10.1016/j.jchf.2013.07.009

10.1016/j.ejheart.2008.08.005

2012, European Journal of Heart Failure, 14, 803, 10.1093/eurjhf/hfs105

2009, Circulation, 119, e391, 10.1161/CIRCULATIONAHA.109.192065

10.1056/nejm199201093260201

10.1093/cvr/cvq308

10.1074/jbc.273.21.13047

10.1093/glycob/10.11.1201

10.1016/j.bbagen.2005.12.020

10.1172/jci200317592

1991, The Journal of Immunology, 147, 2957, 10.4049/jimmunol.147.9.2957

10.1161/01.cir.0000147181.65298.4d

10.1152/ajpheart.00305.2007

10.2353/ajpath.2008.070726

10.1073/pnas.0511167103

10.2353/ajpath.2007.060906

10.1161/01.res.0000141019.20332.3e

10.1074/jbc.275.4.2247

10.1172/JCI200522675

10.1002/(SICI)1097-0215(19990517)81:460;519::AID-IJC362;3.0.CO;2-0

10.2332/allergolint.o-06-449

10.1002/(sici)1096-9896(199903)187:4x0003C;481::aid-path263x003E;3.0.co;2-2

10.1172/jci200214040

10.1097/01.asn.0000111246.87175.32

10.1016/s0002-9440(10)63292-0

10.1177/1074248408329860

10.1056/nejmcp0909392

10.1146/annurev.med.55.091902.104417

10.1093/eurheartj/ehn503

10.1056/nejmcp022709

10.1152/ajpheart.00747.2008

10.3909/ricm0624

2010, Circulation, 122

10.1093/eurjhf/hfp097

10.1371/journal.pone.0058287

10.1016/j.jacc.2010.06.016

10.2147/VHRM.S24509

10.1007/s00392-010-0125-y

2007, Journal of the American College of Cardiology A, 49, article 98

10.1016/j.jacc.2006.03.061

10.1016/j.healun.2008.02.018

10.1373/clinchem.2011.174359

10.5551/jat.12856

10.1038/labinvest.3780131

10.1002/(sici)1097-0215(19990517)81:4x0003C;519::aid-ijc3x003E;3.0.co;2-0

10.2332/allergolint.O-06-449

10.3109/07853890.2010.538080

Thông tin
Thông tin xuất bản

Disease Markers

Tập 2015

1-6

Thông tin tác giả