Production of microparticles of PHBV polymer impregnated with progesterone by supercritical fluid technology

Canadian Journal of Chemical Engineering - Tập 94 Số 7 - Trang 1336-1341 - 2016
Willyan Machado Giufrida1, Fernando Augusto Pedersen Voll2, Andresa Carla Feihrmann3, Marcos H. Kunita4, Ed Hoffmann Madureira5, Marcos R. Guilherme4, Diógenes R. L. Vedoy6, Vladimir Ferreira Cabral1, Lúcio Cardozo‐Filho1
1Department of Chemical Engineering Universidade Estadual de Maringá 87020‐900, Maringá PR Brazil
2Department of Chemical Engineering Universidade Federal do Paraná 81531‐990, Curitiba PR Brazil
3Department of Food Engineering Universidade Estadual de Maringá 87020‐900, Maringá PR Brazil
4Department of Chemistry Universidade Estadual de Maringá 87020‐900, Maringá PR Brazil
5Department of Animal Reproduction University of São Paulo (USP). Av. Duque de Caxias Norte 225, Campus da USP, Pirassununga SP, 13635‐900 Brazil
6Department of Chemical and Materials Engineering, University of Alberta, Edmonton, AB, Canada

Tóm tắt

Abstract

This work reports the synthesis of particles based on poly(3‐hydroxybutirate‐co‐3‐hydroxyvalerate) (PHBV) polymer that were impregnated with progesterone. The PHBV particles were obtained by supercritical CO2 (scCO2) anti‐solvent expansion (SAS). scCO2 was also used at a high pressure (25 MPa) and moderate temperature (323 K) for the impregnation of progesterone into the PHBV particles at different impregnation times. In vitro release tests showed that the half‐time of progesterone release in a hydro‐alcoholic medium, for the samples produced with impregnation times of 2–32 h, was 3–5 h, with the higher release times generally related to smaller impregnation times.

Từ khóa


Tài liệu tham khảo

Hans M. L., 2007, Handbook of Nanoscience, Engineering and Technology, 807

10.1016/j.supflu.2004.10.006

10.1016/j.colsurfb.2010.03.008

10.1016/j.proche.2009.11.004

10.1016/j.colsurfa.2007.05.072

10.1016/j.addr.2004.05.002

10.1016/j.progpolymsci.2011.01.001

10.1002/aic.690490406

10.1016/j.powtec.2004.02.007

10.1016/j.progpolymsci.2005.08.002

10.1016/S1369-703X(03)00038-X

10.1016/j.supflu.2008.02.004

The United States Pharmacopeial Convention “USP XXIII (1995): 1995 U. S. Pharmacopoeia & the National Formulary: USP 23‐NF18 ”U.S. Pharmacopoeial Convention 1994 accessed on August 2015 http://www.usp.org.

Palmer D., 2011, Pharmaceutical Technology, 35, 50

10.1016/j.jcis.2006.12.058

10.1016/j.memsci.2011.07.043

Thông tin
Thông tin xuất bản

Canadian Journal of Chemical Engineering

Tập 94 Số 7

1336-1341

Thông tin tác giả