Production of intrinsically labelled spinach using stable isotopes (13C or15N) for the study of folate absorption

Bentley, 1959, 604 Blount, 1997, Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: Implications for cancer and neuronal damage, Proceedings of the National Academy of Sciences of the United States of America, 94, 3290, 10.1073/pnas.94.7.3290 Bousey, 1995, A quantitative assessment of plasma homocysteine as a risk factor for vascular disease—probable benefits of increasing folic acid intakes, Journal of the American Medical Association, 274, 1049, 10.1001/jama.274.13.1049 Bullock, N. R., Dainty, J., Hart, D., Finglas, P., & Powers, H. J. (2005). The bioavailabilitv of riboflavin from foods. Proceedings of the Nutrition Society, 64 OCA/B, 86A. Chen, 1983, Effects of blanching, freezing and storage on folacin content of spinach, Nutrition Reports International, 28, 317 Cornell CEA programme. (1997) from the website of the Controlled Environment Agriculture Program, Department of Biological and Environmental Engineering, Cornell University, Ithaca, NY. Available at: http://www.bee.cornell.edu/extension/CEA/Spinach_Handbook/sp_spinach_production.htm Czeizel, 1992, Prevention of the first occurrence of neural tube defects by periconceptual vitamin supplementation, New England Journal of Medicine, 327, 32, 10.1056/NEJM199212243272602 Elia, 1998, Nitrogen nutrition, yield and quality of spinach, Journal of the Science of Food and Agriculture, 76, 341, 10.1002/(SICI)1097-0010(199803)76:3<341::AID-JSFA938>3.0.CO;2-4 Fenech, 1999, Aleurone flour is a rich source of bioavailable folate in humans, Journal of Nutrition, 129, 1114, 10.1093/jn/129.6.1114 Gregory, 1997, Bioavailability of folate, European Journal of Clinical Nutrition, 51, S54 Gregory, 2001, Case study: Folate bioavailability, Journal of Nutrition, 131, 1376S, 10.1093/jn/131.4.1376S Gregory, 2002, In-vivo kinetics of folate metabolism, Annual Review of Nutrition, 22, 199, 10.1146/annurev.nutr.22.120701.083554 Gregory, 1984, Fluorometric determination of folacin in biological materials using high performance liquid chromatography, Journal of Nutrition, 114, 341, 10.1093/jn/114.2.341 Hart, 2002, Determination of 5-methyltetrahydrofolate (13C-labelled and unlabeled) in human plasma and urine by combined liquid chromatography mass spectrometry, Analytical Biochemistry, 305, 206, 10.1006/abio.2002.5662 Mason, 1990, Intestinal transport of monoglutamyl folates in mammalian systems, Vol. 13, 47 Nephew, 2003, Epigenetic gene silencing in cancer initiation and progression, Cancer Letters, 190, 125, 10.1016/S0304-3835(02)00511-6 Pfeiffer, 1997, Determination of folate in cereal-grain food products using trienzyme extraction and combined affinity and reversed-phase liquid chromatography, Journal of Agricultural and Food Chemistry, 45, 407, 10.1021/jf960633q Prinz-Langenohl, 1999, Availability of food folate in humans, Journal of Nutrition, 29, 913, 10.1093/jn/129.4.913 Sanderson, 2003, Folate bioavailability: UK Food Standards Agency workshop report, British Journal of Nutrition, 90, 473, 10.1079/BJN2003889 Scott, 1976, Folate composition, synthesis and function in natural materials, Clinics in Haematology, 5, 547, 10.1016/S0308-2261(21)00110-7 Selhub, 1983, Gastrointestinal absorption of folates and anti folates, Pharmacology & Therapeutics, 20, 397, 10.1016/0163-7258(83)90034-7 Shane, 1995, Folate chemistry and metabolism, l Steinberg, 1984, Mechanisms of folate homeostasis, American Journal of Physiology, 246, G319 Strum, 1979, Enzymatic reduction and methylation of folate following pH-dependant, carrier-mediated transport in rat jejunum, Biochimica et Biophysica Acta, 554, 249, 10.1016/0005-2736(79)90022-1 Wald, 1991, Prevention of neural tube defects: Results of the Medical Research Council Vitamin Study, Lancet, 338, 131 Wright, 2003, Single oral doses of 13C forms of pteroylmonoglutamic acid and 5-formyltetrahydrofolic acid elicit differences in short term kinetics of labelled and unlabelled folates in plasma: Potential problems in interpretation of folate bioavailability studies, British Journal of Nutrition, 90, 363, 10.1079/BJN2003908 Wright, 2005, Differential kinetic behavior and distribution for pteroylglutamic acid and reduced folates: A revised hypothesis of the primary site of PteGlu metabolism in humans, Journal of Nutrition, 135, 619, 10.1093/jn/135.3.619