Production of BMP4 by endothelial cells is crucial for endogenous thymic regeneration

Science immunology - Tập 3 Số 19 - 2018
Tobias Wertheimer1,2, Enrico Velardi2, Jennifer J. Tsai2,3, Kenneth W. Cooper3, Shiyun Xiao4, Christopher C. Kloss5,6, Katja J. Jarick7, Zeinab Mokhtari7, Christian Brede7, Paul deRoos3, Sinéad Kinsella3, Brisa Palikuqi6, Michael Ginsberg8, Lauren Young2, Fabiana M. Kreines2, Sophie Lieberman2, Amina Lazrak2, Peipei Guo6, Florent Malard2, Odette M. Smith2, Yusuke Shono2, Robert R. Jenq9, Alan M. Hanash9, Daniel J. Nolan8, Jason M. Butler6, Andreas Beilhack7, Nancy R. Manley4, Shahin Rafii6, Jarrod A. Dudakov10,3, Marcel R.M. van den Brink9,2
1Division of Hematology and Oncology, Department of Medicine, Freiburg University Medical Center, Albert-Ludwigs-University, 79106 Freiburg, Germany.
2Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
3Program in Immunology, Clinical Research Division, and Immunotherapy Integrated Research Center, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
4Department of Genetics, University of Georgia, Athens, GA 30602, USA
5Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
6Department of Genetic Medicine and Ansary Stem Cell Institute, Weill Cornell Medical College, New York, NY 10021, USA
7Department of Medicine II, Würzburg University Hospital, Interdisciplinary Center for Clinical Research (IZKF), and Graduate School of Life Sciences, University of Würzburg, Würzburg, Germany.
8Angiocrine Bioscience, San Diego, CA 92130, USA.
9Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, 10065 USA
10Department of Immunology, University of Washington, Seattle, WA 98109, USA

Tóm tắt

BMP4 produced by endothelial cells promotes thymic regeneration after acute damage by activating FOXN1 and its downstream targets.

Từ khóa


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Science immunology

Tập 3 Số 19

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