Probiotic Soy Milk Consumption and Renal Function Among Type 2 Diabetic Patients with Nephropathy: a Randomized Controlled Clinical Trial
Tóm tắt
Diabetic nephropathy (DN) is one the most important complications of diabetes leading to end-stage renal disease. Dietary approaches have been considered to control of the kidney function deterioration among these patients. The aim of the present study was to determine the effects of fortified soy milk with Lactobacillus plantarum A7 on renal function biomarkers in type 2 DN patients. Forty-eight DN subjects were attended to this parallel randomized trial study. Participants were randomly assigned to consume a diet containing 200 mL/day probiotic soy milk in intervention group or soy milk in the control condition for 8 weeks. An inflammatory adipokine—Progranulin (PGRN), a cytokine receptor-soluble tumor necrosis factor receptor 1 (sTNFR1), and serum levels of Neutrophil gelatinase-associated lipocalin (NGAL) and cystatin C (Cys-C) as the new renal function biomarkers were measured after 8 weeks of intervention according to the standard protocol. Our analysis showed that consumption of probiotic soy milk resulted in a significant reduction in the Cys-C and PGRN levels compared with the soy milk (P = 0.01) in the final adjusted model. In addition, after adjustment for age, weight, and energy intake, a marginally significant in the NGAL level was seen between two groups (P = 0.05). However, there was no significant differences on the sTNFR1concenteration between two groups (P = 0.06). Overall, intake of probiotic soy milk may have a beneficial effect on the renal function in patients with DN.
Tài liệu tham khảo
Eboh C, Chowdhury TA (2015) Management of diabetic renal disease. Ann Transl Med 3:154. https://doi.org/10.3978/j.issn.2305-5839.2015.06.25
Azimi P, Ghiasvand R, Feizi A, Hosseinzadeh J, Bahreynian M, Hariri M, Khosravi-Boroujeni H (2016) Effect of cinnamon, cardamom, saffron and ginger consumption on blood pressure and a marker of endothelial function in patients with type 2 diabetes mellitus: a randomized controlled clinical trial. Blood Press 3:133–140. https://doi.org/10.3109/08037051.2015.1111020
Lala MA, Nazar CMJ, Lala HA, Singh JK (2015) Interrelation between blood pressure and diabetes. J Renal Endocrinol 1(1):e05
Amiri M (2016) Diabetes mellitus type 2; an international challenge. Ann Res Dial 1:e04.
Zhao J, Zhu Y, Hyun N, Zeng D, Uppal K, Tran VT, Yu T, Jones D, He J, Lee ET, Howard BV (2015) Novel metabolic markers for the risk of diabetes development in American Indians. Diabetes Care 38:220–227. https://doi.org/10.2337/dc14-2033
Mahboobi S, Iraj B, Maghsoudi Z, Feizi A, Ghiasvand R, Askari G, Maayeshi N (2014) The effects of probiotic supplementation on markers of blood lipids, and blood pressure in patients with prediabetes: a randomized clinical trial. Int J Prev Med 5:1239–1246
Nasri H (2013) On the occasion of the world diabetes day 2013; diabetes education and prevention; a nephrology point of view. J Renal Inj Prev 2:31
Ardalan M-R, Nasri H (2014) Lessons from our paleolithic primogenitors; a short look to the world diabetes day 2014 with the theme of “healthy living and diabetes”. J Parathyr Dis 2:57–58
Whitham D (2014) Nutrition for the prevention and treatment of chronic kidney disease in diabetes. Can J Diabetes 38:344–348. https://doi.org/10.1016/j.jcjd.2014.07.222
Nasri H (2016) From intestine to kidney; a narrative literature review. Acta Persica Pathophysiologica 1:e03
Meek RL, LeBoeuf RC, Saha SA, Alpers CE, Hudkins KL, Cooney SK, Anderberg RJ, Tuttle KR (2013) Glomerular cell death and inflammation with high-protein diet and diabetes. Nephrol Dial Transplant 28:1711–1720. https://doi.org/10.1093/ndt/gfs579
Miraghajani MS, Esmaillzadeh A, Najafabadi MM, Mirlohi M, Azadbakht L (2012) Soy milk consumption, inflammation, coagulation, and oxidative stress among type 2 diabetic patients with nephropathy. Diabetes Care 35:1981–1985. https://doi.org/10.2337/dc12-0250
Baharvand-Ahmadi B, Bahmani M, Tajeddini P, Naghdi N, Rafieian-Kopaei M (2016) An ethno-medicinal study of medicinal plants used for the treatment of diabetes. J Nephropathol 5:44
Patel R, DuPont HL (2015) New approaches for bacteriotherapy: prebiotics, new-generation probiotics, and synbiotics. Clin Infect Dis 2:S108–S121. https://doi.org/10.1093/cid/civ177
Asemi Z, Zare Z, Shakeri H, Sabihi SS, Esmaillzadeh A (2013) Effect of multispecies probiotic supplements on metabolic profiles, hs-CRP, and oxidative stress in patients with type 2 diabetes. Ann Nutr Metab 63:1–9. https://doi.org/10.1159/000349922
Zaman Huri H, Fun Wee H (2013) Drug related problems in type 2 diabetes patients with hypertension: a cross-sectional retrospective study. BMC Endocr Disord 13:2. https://doi.org/10.1186/1472-6823-13-2
Nasri H (2016) A short look to the nephroprotective impacts of metformin. Toxicologia Persa 1:e01
Miraghajani MS, Najafabadi MM, Surkan PJ, Esmaillzadeh A, Mirlohi M, Azadbakht L (2013) Soy milk consumption and blood pressure among type 2 diabetic patients with nephropathy. J Renal Nutr: Off J Council Renal Nutr National Kidney Found 23(277–282):e271. https://doi.org/10.1053/j.jrn.2013.01.017
Hariri M, Salehi R, Feizi A, Mirlohi M, Ghiasvand R, Habibi N (2015) A randomized, double-blind, placebo-controlled, clinical trial on probiotic soy milk and soy milk: effects on epigenetics and oxidative stress in patients with type II diabetes. Genes Nutr 10:52. https://doi.org/10.1007/s12263-015-0503-1
Hojs R, Ekart R, Bevc S, Hojs N (2015) Biomarkers of renal disease and progression in patients with diabetes. J Clin Med 4:1010–1024. https://doi.org/10.3390/jcm4051010
Azadbakht L, Atabak S, Esmaillzadeh A (2008) Soy protein intake, cardiorenal indices, and C-reactive protein in type 2 diabetes with nephropathy: a longitudinal randomized clinical trial. Diabetes Care 31:648–654. https://doi.org/10.2337/dc07-2065
Babashahi M, Mirlohi M, Ghiasvand R, Azadbakht L (2015) Comparison of soymilk and probiotic soymilk effects on serum high-density lipoprotein cholesterol and low-density lipoprotein cholesterol in diabetic Wistar rats. ARYA Atheroscler 11:88–93
Takagi A, Kano M, Kaga C (2015) Possibility of breast cancer prevention: use of soy isoflavones and fermented soy beverage produced using probiotics. Int J Mol Sci 16:10907–10920. https://doi.org/10.3390/ijms160510907
Yang SO, Kim SH, Cho S, Lee J, Kim YS, Yun SS, Choi HK (2009) Classification of fermented soymilk during fermentation by 1H NMR coupled with principal component analysis and elucidation of free-radical scavenging activities. Biosci Biotechnol Biochem 73:1184–1188. https://doi.org/10.1271/bbb.80743
Fiseha T (2015) Urinary biomarkers for early diabetic nephropathy in type 2 diabetic patients. Biomarker Res 3:16. https://doi.org/10.1186/s40364-015-0042-3
Abbasi B, Ghiasvand R, Mirlohi M (2017) Kidney function improvement by soy milk containing Lactobacillus plantarum A7 in type 2 diabetic patients with nephropathy: a double-blinded randomized controlled trial. Iran J Kidney Dis 11:36–43
Wang IK, Wu YY, Yang YF, Ting IW, Lin CC, Yen TH, Chen JH, Wang CH, Huang CC, Lin HC (2015) The effect of probiotics on serum levels of cytokine and endotoxin in peritoneal dialysis patients: a randomised, double-blind, placebo-controlled trial. Benef Microbes 6:423–430. https://doi.org/10.3920/BM2014.0088
Liu ZM, Ho SC, Chen YM, Tang N, Woo J (2014) Effect of whole soy and purified isoflavone daidzein on renal function--a 6-month randomized controlled trial in equol-producing postmenopausal women with prehypertension. Clin Biochem 47:1250–1256. https://doi.org/10.1016/j.clinbiochem.2014.05.054
Nicoletto BB, Canani LH (2015) The role of progranulin in diabetes and kidney disease. Diabetol Metab Syndr 7:117. https://doi.org/10.1186/s13098-015-0112-6
Gomes AC, Bueno AA, de Souza RG, Mota JF (2014) Gut microbiota, probiotics and diabetes. Nutr J 13:60. https://doi.org/10.1186/1475-2891-13-60
Zarrati M, Salehi E, Nourijelyani K, Mofid V, Zadeh MJ, Najafi F, Ghaflati Z, Bidad K, Chamari M, Karimi M, Shidfar F (2014) Effects of probiotic yogurt on fat distribution and gene expression of proinflammatory factors in peripheral blood mononuclear cells in overweight and obese people with or without weight-loss diet. J Am Coll Nutr 33:417–425. https://doi.org/10.1080/07315724.2013.874937
Gohda T, Tomino Y (2013) Novel biomarkers for the progression of diabetic nephropathy: soluble TNF receptors. Curr Diab Rep 13(4):560–566. https://doi.org/10.1007/s11892-013-0385-9
Gohda T, Niewczas MA, Ficociello LH, Walker WH, Skupien J, Rosetti F, Cullere X, Johnson AC, Crabtree G, Smiles AM, Mayadas TN, Warram JH, Krolewski AS (2012) Circulating TNF receptors 1 and 2 predict stage 3 CKD in type 1 diabetes. J Am Soc Nephrol 23:516–524. https://doi.org/10.1681/ASN.2011060628
Fernandez-Real JM, Lainez B, Vendrell J, Rigla M, Castro A, Penarroja G, Broch M, Perez A, Richart C, Engel P, Ricart W (2002) Shedding of TNF-alpha receptors, blood pressure, and insulin sensitivity in type 2 diabetes mellitus. Am J Physiol Endocrinol Metab 282:E952–E959. https://doi.org/10.1152/ajpendo.00444.2001
Stadlbauer V, Mookerjee RP, Hodges S, Wright GA, Davies NA, Jalan R (2008) Effect of probiotic treatment on deranged neutrophil function and cytokine responses in patients with compensated alcoholic cirrhosis. J Hepatol 48:945–951. https://doi.org/10.1016/j.jhep.2008.02.015
Wu SH, Shu XO, Chow WH, Xiang YB, Zhang X, Li HL, Cai Q, Ji BT, Cai H, Rothman N, Gao YT, Zheng W, Yang G (2012) Soy food intake and circulating levels of inflammatory markers in Chinese women. J Acad Nutr Diet 112:996–1004, 1004 e1001-1004. https://doi.org/10.1016/j.jand.2012.04.001
See D, Mason S, Roshan R (2002) Increased tumor necrosis factor alpha (TNF-alpha) and natural killer cell (NK) function using an integrative approach in late stage cancers. Immunol Investig 31:137–153
Miraghajani M, Zaghian N, Mirlohi M, Feizi A, Ghiasvand R (2017) The impact of probiotic soy milk consumption on oxidative stress among type 2 diabetic kidney disease patients: a randomized controlled clinical trial. Journal of Renal Nutrition 27:317-324.
Shahreza FD (2016) From oxidative stress to endothelial cell dysfunction. J Prev Epidemiol 1:e04
Shahreza FD (2016) Mechanistic impact of renal tubular cell protection by antioxidants. Ann Res Antioxid 1:e11
Sabatino A, Regolisti G, Cosola C, Gesualdo L, Fiaccadori E (2017) Intestinal microbiota in type 2 diabetes and chronic kidney disease. Curr Diab Rep 17:16
Han JL, Lin HL (2014) Intestinal microbiota and type 2 diabetes: from mechanism insights to therapeutic perspective. World J Gastroentero 20:17737–17745. https://doi.org/10.3748/wjg.v20.i47.17737
Gomes AC, Bueno AA, de Souza RGM, Mota JF (2014) Gut microbiota, probiotics and diabetes. Nutr J 13. https://doi.org/10.1186/1475-2891-13-60
Nasri H (2016) Aggravating role of inflammation in diabetic kidney disease. J Inj Inflamm 1:e03
Tian P, Li B, He C, Song W, Hou A, Tian S, Meng X, Li K, Shan Y (2016) Antidiabetic (type 2) effects of Lactobacillus G15 and Q14 in rats through regulation of intestinal permeability and microbiota. Food Funct 7:3789–3797
Razmpoosh E, Javadi M, Ejtahed HS, Mirmiran P (2016) Probiotics as beneficial agents in the management of diabetes mellitus: a systematic review. Diabetes Metab Res Rev 32:143–168
Rad A, Sahhaf F, Hassanalilou T, Ejtahed H, Motayagheni N, Soroush A, Javadi M, Mortazavian A, Khalili L (2016) Diabetes management by probiotics: current knowledge and future perspectives. Current diabetes reviews https://www.ncbi.nlm.nih.gov/labs/articles/27758705/