Prevention of Developmental Delays in a Down Syndrome Mouse Model

Dolk, 2005, Trends and geographic inequalities in the prevalence of Down syndrome in Europe, 1980-1999., Rev Epidemiol Sante Publique, 53, 2S87, 10.1016/S0398-7620(05)84771-6

Vicari, 2006, Motor development and neuropsychological patterns in persons with Down syndrome., Behav Genet, 36, 355, 10.1007/s10519-006-9057-8

Chen, 2005, Sensory evoked potentials in infants with Down syndrome., Acta Paediatr, 94, 1615, 10.1080/08035250500252609

Toledo, 1999, Growth curves of children with Down syndrome., Ann Genet, 42, 81

Nadel, 2003, Down’s syndrome: a genetic disorder in biobehavioral perspective, Genes Brain Behav, 2, 156, 10.1034/j.1601-183X.2003.00026.x

Davisson, 1990, Segmental trisomy of murine chromosome 16: a new model system for studying Down syndrome., Prog Clin Biol Res, 360, 263

Holtzman, 1996, Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome., Proc Natl Acad Sci USA, 93, 13333, 10.1073/pnas.93.23.13333

Belichenko, 2004, Synaptic structural abnormalities in the Ts65Dn mouse model of Down Syndrome., J Comp Neurol, 480, 281, 10.1002/cne.20337

Contestabile, 2007, Cell cycle alteration and decreased cell proliferation in the hippocampal dentate gyrus and in the neocortical germinal matrix of fetuses with Down syndrome and in Ts65Dn mice., Hippocampus, 17, 665, 10.1002/hipo.20308

Best, 2007, Ts65Dn, a mouse model of Down syndrome, exhibits increased GABAB-induced potassium current., J Neurophisiol, 97, 892, 10.1152/jn.00626.2006

Nelson, 2006, Selected neurotrophins, neuropeptides, and cytokines: developmental trajectory and concentrations in neonatal blood of children with autism or Down syndrome., Int J Dev Neurosci, 24, 73, 10.1016/j.ijdevneu.2005.10.003

Hill, 2003, Vasoactive intestinal peptide in the brain of a mouse model for Down syndrome., Exp Neurol, 183, 56, 10.1016/S0014-4886(03)00164-X

Sahir, 2006, Neonatal mice of the Down syndrome model, Ts65Dn, exhibit upregulated VIP measures and reduced responsiveness of cortical astrocytes to VIP stimulation., J Mol Neurosci, 30, 329, 10.1385/JMN:30:3:329

Wu, 1997, Neurobehavioral development of neonatal mice following blockade of VIP during the early embryonic period., Peptides, 18, 1131, 10.1016/S0196-9781(97)00146-0

Brenneman, 2004, Protective peptides that are orally active and mechanistically nonchiral., J Pharmacol Exp Ther, 309, 1190, 10.1124/jpet.103.063891

Busciglio, 2007, NAP and ADNF-9 protect normal and Down’s syndrome cortical neurons from oxidative damage and apoptosis., Curr Pharm Des, 13, 1091, 10.2174/138161207780618957

Spong, 2001, Prevention of fetal demise and growth restriction in a mouse model of fetal alcohol syndrome., J Pharmacol Exp Ther, 297, 774

Vink, 2005, Novel peptides prevent alcohol-induced spatial learning deficits and proinflammatory cytokine release in a mouse model of fetal alcohol syndrome., Am J Obstet Gynecol, 193, 825, 10.1016/j.ajog.2005.02.101

Spong, 1999, Maternal regulation of embryonic growth: the role of vasoactive intestinal peptide., Endocrinology, 140, 917, 10.1210/endo.140.2.6481

Fox, 1965, Reflex-ontogeny and behavioural development of the mouse., Anim Behav, 13, 234, 10.1016/0003-3472(65)90041-2

Santucci, 1993, Neonatal exposure to bFGF exerts NGF-like effects on mouse behavioral development., Neurotoxicol Teratol, 15, 131, 10.1016/0892-0362(93)90071-U

Liu, 2003, Quantitative PCR genotyping assay for the Ts65Dn mouse model of Down syndrome., Biotechniques, 35, 1170, 10.2144/03356st02

Truett, 2000, Preparation of PCR-quality mouse genomic DNA with hot sodium hydroxide and tris (HotSHOT)., Biotechniques, 29, 52, 10.2144/00291bm09

Reeves, 1995, A mouse model for Down syndrome exhibits learning and behavior deficits., Nat Genet, 11, 177, 10.1038/ng1095-177

Toso, 2006, Learning enhancement with neuropeptides., Am J Obstet Gynecol, 194, 1153, 10.1016/j.ajog.2005.12.023