Prevalence of Metastasis at Diagnosis of Osteosarcoma: An International Comparison

Pediatric Blood and Cancer - Tập 63 Số 6 - Trang 1006-1011 - 2016
Tracy A. Marko1, Brandon J. Diessner2, Logan G. Spector3
1Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota
2School of Public Health, University of Minnesota, Minneapolis, Minnesota
3Department of Pediatric Epidemiology, University of Minnesota, Minneapolis, Minnesota

Tóm tắt

BackgroundOsteosarcoma (OS) is the most common primary malignant bone tumor in many countries, with metastatic disease responsible for most patient deaths. This study compares the prevalence of metastatic OS at diagnosis across countries to inform the critical question of whether diagnostic delay or tumor biology drives metastases development prior to diagnosis.ProcedureA literature search of the PubMed database was conducted to compare the prevalence of metastatic disease at the time of OS diagnosis between countries. A pooled prevalence with 95% confidence intervals was calculated for each study meeting inclusion criteria. Studies were grouped for analysis based on human development index (HDI) scores.ResultsOur analysis found an 18% (95% confidence interval [CI]: 15%, 20%) average global pooled proportion of metastasis at OS diagnosis. The average prevalence of metastasis at diagnosis increased as HDI groupings decreased, with very high HDI, high HDI, and medium/low HDI groups found to be 15% (95% CI: 13%, 17%), 20% (95% CI: 14%, 28%), and 31% (95% CI: 15%, 52%), respectively.ConclusionsOur evidence suggests there is a biological baseline for metastatic OS at diagnosis, which is observed in countries with very high HDI. In countries with medium/low HDI, where there are more barriers to accessing healthcare, the higher prevalence of metastasis may result from treatment delay or an artificial prevalence inflation due to patients with less severe symptoms not presenting to clinic. Additional research in countries with medium/low HDI may reveal that earlier detection and treatment could improve patient outcomes in those countries.

Từ khóa


Tài liệu tham khảo

10.1111/apa.12986

10.1002/cncr.27816

Tan LL, 2001, Pattern of primary musculoskeletal sarcomas referred to Institute of Radiotherapy and Oncology, Hospital Kuala Lumpur, 1995–1999, Med J Malaysia, 56, 52

10.1002/ijc.24320

10.1002/cncr.24121

10.3109/0284186X.2014.923934

10.1186/1750-1172-2-6

10.1200/JCO.2002.20.3.776

10.2106/JBJS.L.01189

10.1245/ASO.2004.03.004

Tang S, 2015, Surgical treatment and prognostic analysis of osteosarcoma in adults older than 40 years, Beijing Da Xue Xue Bao, 47, 165

10.7314/APJCP.2014.15.8.3537

10.1002/pbc.23172

10.1002/(SICI)1096-9098(199911)72:3<124::AID-JSO3>3.0.CO;2-G

10.3109/02841869609098531

Duong LM, 2013, Descriptive epidemiology of malignant primary osteosarcoma using population‐based registries, United States, 1999–2008, J Registry Manag, 40, 59

10.1016/0197-2456(86)90046-2

10.2307/3001666

10.1002/sim.1186

R Core Team. R: A language and environment for statistical computing. R Foundation for Statistical Computing: Vienna Austria 2015.http://www.R‐project.org/ 2015. Accessed July 1 2015.

10.1002/1097-0142(19811015)48:8<1719::AID-CNCR2820480806>3.0.CO;2-J

10.1111/j.1445-2197.1997.tb04611.x

Bokemeyer C, 1993, Treatment of adult osteosarcoma—Single‐center results in 47 patients, Int J Oncol, 3, 927

10.1093/annonc/mdn731

10.1007/s00247-010-1809-1

10.1302/0301-620X.89B9.19255

Meskens M, 1993, Osteogenic sarcoma in children. A retrospective study of 58 cases, Acta Orthop Belg, 59, 64

Babin SR, 1996, High grade osteosarcoma of the lower limb. Complications and results of the treatment of 20 patients, Rev Chir Orthop Reparatrice Appar Mot, 82, 14

10.1080/17453670810016966

10.1002/1097-0142(19811001)48:7<1569::AID-CNCR2820480717>3.0.CO;2-X

10.1093/annonc/mdp502

10.1200/JCO.2007.14.9104

Adamkova Krakorova D, 2012, Analysis of prognostic factors in osteosarcoma adult patients, a single institution experience, Klin Onkol, 25, 346

10.1007/s11999-010-1423-4

10.1245/s10434-015-4414-6

10.1111/ajco.12346

10.1007/s12032-013-0624-6

Varan A, 2007, Treatment results of pediatric osteosarcoma: Twenty‐year experience, J Pediatr Orthop, 27, 241

Pochanugool L, 1997, Osteosarcoma: A study of 130 cases, J Med Assoc Thai, 80, 153

Aouad AM, 1994, Experience of treatment of osteogenic sarcoma at the University Hospital Center of Alexandria (Egypt): Retrospective study of 105 cases, Bull Cancer, 81, 698

10.7196/samj.5835

10.1007/978-1-4615-3518-8_46

10.1186/1477-7819-9-51

10.1155/2012/704872

10.1097/BLO.0b013e3180f62608

Yang JY, 2009, Initial presentation and management of osteosarcoma, and its impact on disease outcome, Hong Kong Med J, 15, 434

10.1245/s10434-014-4154-z

10.1097/00043426-200201000-00008

Thông tin
Thông tin xuất bản

Pediatric Blood and Cancer

Tập 63 Số 6

1006-1011

Thông tin tác giả