Tỉ lệ nhiễm Helicobacter pylori ở bệnh nhân Sudan được chẩn đoán mắc polyp đại tràng và ung thư đại tràng bằng kỹ thuật nhuộm miễn dịch mô học

Springer Science and Business Media LLC - Tập 13 Số 1 - 2020
Abdelrahim Osman Mohamed1, Nazik M. Elhassan1, Zahra A. Awhag1, Fadwa S. Ali1, Eman Ali2,1, Najwa A. Mhmoud3, Emmanuel Edwar Siddig4,5,6, Rowa Hassan5, Eiman Siddig Ahmed5, Azam Fattahi7, Ayman Ahmed8, Mohamed S. Muneer9,10,11, Hussam A. Osman12, Nouh Saad Mohamed13,14,15, Ali Mahmoud Mohammed Edris1,16
1Department of Histopathology and Cytology, Faculty of Medical Laboratory Sciences, University of Khartoum, Khartoum, Sudan
2Department of Histopathology and Cytology, Faculty of Medical Laboratory Sciences, National University, Sudan, Khartoum, Sudan
3Department of Microbiology and Immunology, Faculty of Medical Laboratory Sciences, University of Khartoum, Khartoum, Sudan
4Department of Histopathology and Cytology, Alfarrabi College for Science and Technology, Khartoum, Sudan
5Mycetoma Research Center, University of Khartoum, Khartoum, Sudan
6School of Medicine, Nile University, Khartoum, Sudan
7Center for Research and Training in Skin Disease and Leprosy, Tehran University of Medical Sciences, Tehran, Iran
8Department of Parasitology and Medical Entomology, Institute of Endemic Diseases, University of Khartoum, Khartoum, Sudan
9Department of Internal Medicine, Faculty of Medicine, University of Khartoum, Khartoum, Sudan
10Department of Neurology, Mayo Clinic, Jacksonville, USA
11Department of Radiology, Mayo Clinic, Jacksonville, USA
12Biomedical Research Laboratory, Ahfad University for Women, Omdurman, Sudan
13Department of Parasitology and Medical Entomology, Faculty of Medical Laboratory Sciences, Nile University, Khartoum, Sudan
14Department of Parasitology and Medical Entomology, Faculty of Medicine, Sinnar University, Sinnar, Sudan
15Molecular Biology Department, Alfarrabi College for sciences and Technology, Khartoum, Sudan
16Faculty of Applied Medical Sciences, University of Bisha, Bisha, Kingdom of Saudi Arabia

Tóm tắt

Tiêu đề tóm tắt Mục tiêu Nhiễm khuẩn với vi khuẩn Helicobacter pylori đã được phân loại là chất gây ung thư nhóm một, liên quan đến sự tăng cường độ nhạy cảm đối với viêm dạ dày và ung thư dạ dày. Nghiên cứu này nhằm mục đích điều tra tỉ lệ nhiễm H. pylori ở bệnh nhân mắc polyp đại tràng và ung thư đại tràng. Một nghiên cứu mô tả cắt ngang dựa trên bệnh viện đã được thực hiện từ tháng Hai đến tháng Sáu năm 2017. Chín mươi chín mẫu mô cố định trong formalin từ bệnh nhân polyp đại tràng và ung thư đại tràng đã được thu thập để phát hiện H. pylori bằng kỹ thuật nhuộm miễn dịch mô học. Kết quả Trong số 69 bệnh nhân được đưa vào nghiên cứu, có 39 nam (56.5%) và 30 nữ (43.5%), độ tuổi của họ dao động từ 21 đến 80 tuổi với độ tuổi trung bình là 47.1 ± 19.7. Trong số 69 bệnh nhân mắc polyp đại tràng và ung thư đại tràng, 44 bệnh nhân (63.8%) được chẩn đoán mắc adenocarcinoma, 10 (14.5%) bệnh nhân mắc viêm đại tràng, 15 (21.7%) bệnh nhân mắc hội chứng polyp thanh thiếu niên. Kết quả của kỹ thuật nhuộm miễn dịch mô học cho thấy có 16 bệnh nhân (23.2%) dương tính với nhiễm H. pylori. Trong số 16 bệnh nhân này, có 13 (81.3%) bệnh nhân được chẩn đoán mắc adenocarcinoma và 3 (18.7%) bệnh nhân được chẩn đoán mắc polyp thanh thiếu niên. Kết quả phát hiện H. pylori giữa các bệnh nhân polyp đại tràng và ung thư đại tràng cho thấy mối liên kết có ý nghĩa thống kê giữa nhiễm H. pylori và adenocarcinoma, giá trị P là 0.028.

Từ khóa

#Helicobacter pylori #ung thư đại tràng #polyp đại tràng #nhuộm miễn dịch mô học #adenocarcinoma

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