Prevalence, incidence of and risk factors for vertebral fracture in the community: the Vietnam Osteoporosis Study

Scientific Reports - Tập 14 - Trang 1-7 - 2024
Hoa T. Nguyen1,2,3, Bao T. Nguyen2, Thi H. Nhung Thai2, An V. Tran2, Tan T. Nguyen2, Tam Vo1, Linh D. Mai4,3,5, Thach S. Tran3,6, Tuan V. Nguyen7,6, Lan T. Ho-Pham4,3,5
1Department of Internal Medicine, University of Medicine and Pharmacy, Hue University, Hue, Vietnam
2Can Tho University of Medicine and Pharmacy, Faculty of Medicine, Can Tho, Vietnam
3Saigon Precision Medicine Research Center, Ho Chi Minh City, Vietnam
4Biomedicine Research Center Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Vietnam
5Bone and Muscle Research Group, Ton Duc Thang University, Ho Chi Minh City, Vietnam
6School of Biomedical Engineering, University of Technology Sydney, Ultimo, Australia
7Tam Anh Research Institute, Tam Anh Hospital, Ho Chi Minh City, Vietnam

Tóm tắt

The epidemiology of vertebral fractures (VF) in underrepresented populations is not well-documented. This cohort study was part of a longitudinal osteoporosis research project with the aim of determining the prevalence, incidence, and risk factors for VF. 401 individuals (155 men) aged 50 years and older without a clinical diagnosis of VF were took radiographs at baseline and 2 years later. VF were ascertained using the Genant's semi-quantitative method. Bone mineral density (BMD) of femoral neck and lumbar spine were measured by dual-energy X-ray absorptiometry (Hologic Inc). The association between VF and risk factors was analyzed by the multiple logistic regression. The 95% confidence interval for prevalence and incidence was estimated by exact Poisson test. At baseline, the prevalence of VF was 12.2% (n = 49, 95% CI 9.0–16.2%) and increased with advancing age with one-fifth of those aged 70 and older having a VF. During the follow-up period, we observed 6 new VF, making the incidence of 6.6/1000 person-years (n = 6, 95% CI 2.4–14.3). The risk of prevalent VF was associated with male gender (OR: 2.67; 95% CI 1.28–5.87) and T-score at the femoral neck (OR per one SD decrease: 1.1; 1.03–1.17). These data indicate that VF is common among adults, and that lower femoral neck BMD was a risk factor for VF.

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