Prevalence and risk factors of post-COVID-19 condition in adults and children at 6 and 12 months after hospital discharge: a prospective, cohort study in Moscow (StopCOVID)

BMC Medicine - 2022
Ekaterina Pazukhina1,2, Margarita Andreeva, Ekaterina Spiridonova, Polina Bobkova, Anastasia Shikhaleva, Yasmin El‐Taravi, Mikhail Rumyantsev, Aysylu Gamirova, Anastasiia Bairashevskaia, Polina Petrova, Dina Baimukhambetova, Maria Pikuza, Elina Abdeeva, Yulia Filippova, Salima Deunezhewa, Nikita Nekliudov, Polina Bugaeva, Nikolay Bulanov, С. Н. Авдеев, Валентина Капустина, Alla Guekht, Audrey DunnGalvin, Pasquale Comberiati, Diego Peroni, Christian Apfelbacher, Jon Genuneit, Luis Felipe Reyes, Caroline L H Brackel, Victоr Fоmin, Andrey Svistunov, Peter Timashev, Lyudmila Mazankova, Alexandra Miroshina, Э. Р. Самитова, С. Н. Борзакова, Elena Bondarenko, Anatoliy A. Korsunskiy, Gail Carson, Louise Sigfrid, Janet T. Scott, Matthew Greenhawt, Danilo Buonsenso, Malcolm G Semple, John O. Warner, Piero Olliaro, Dale M. Needham, П. В. Глыбочко, Denis Butnaru, И. М. Османов, Daniel Munblit, Nikol Alekseeva, Elena Artigas, Asmik Avagyan, Lusine Baziyants, Anna C. Belkina, Anna Berbenyuk, Tatiana Bezbabicheva, Vadim Bezrukov, Semyon Bordyugov, Aleksandra Borisenko, Maria Bratukhina, Ekaterina Bugaiskaya, Julia Chayka, Yulia Cherdantseva, Natalia Degtyareva, Olesya Druzhkova, А. В. Дубинин, Khalisa Elifkhanova, D. Eliseev, Anastasia Ezhova, Aleksandra Frolova, Julia Ganieva, Anastasia Gorina, Cyrill Gorlenko, Elizaveta Gribaleva, Eliza Gudratova, Shabnam Ibragimova, Khadizhat Kabieva, Yulia Kalan, Margarita Kalinina, Nadezhda Khitrina, Bogdan Kirillov, Herman Kiseljow, Maria Kislova, Natalya Kogut, Irina Konova, Mariia Korgunova, Anastasia Kotelnikova, Karina Kovygina, Alexandra Krupina, Anastasia Kuznetsova, А. С. Кузнецова, Baina Lavginova, Elza Lidjieva, Ekaterina Listovskaya, Maria Lobova, Maria Loshkareva, Ekaterina V. Lyubimova, Daria Mamchich, Nadezhda Markina, Anastasia Maystrenko, Aigun Mursalova, Evgeniy Nagornov, A. A. Nartova, Daria Nikolaeva, Georgiy Novoselov, Marina Ogandzhanova, Anna Pavlenko, Olga Perekosova, Erika Porubayeva, Kristina Presnyakova, Anna Pushkareva, Olga E. Romanova, Philipp Roshchin, Diana Salakhova, Ilona Sarukhanyan, Victoria Savina, Jamilya Shatrova, Nataliya Shishkina, Anastasia Shvedova, Denis A. Smirnov, V S Solovieva, Olga Spasskaya, Olga Sukhodolskaya, С. Ш. Сулейманов, Nailya Urmantaeva, Olga Usalka, Valeria Ustyan, Yana Valieva, Katerina Varaksina, Maria Varaksina, Ekaterina Varlamova, Maria Vodianova, Margarita Yegiyan, M. P. Zaikina, Anastasia Zorina, Elena I. Zuykova
1Macroeconomic Analysis and Financial Statistics, Financial Research Institute of the Ministry of Finance of the Russian Federation
2Institute of Applied Economic Studies, The Russian Presidential Academy of National Economy and Public Administration

Tóm tắt

Abstract Background Previous studies assessing the prevalence of COVID-19 sequelae in adults and children were performed in the absence of an agreed definition. We investigated prevalence of post-COVID-19 condition (PCC) (WHO definition), at 6- and 12-months follow-up, amongst previously hospitalised adults and children and assessed risk factors. Methods Prospective cohort study of children and adults with confirmed COVID-19 in Moscow, hospitalised between April and August, 2020. Two follow-up telephone interviews, using the International Severe Acute Respiratory and Emerging Infection Consortium survey, were performed at 6 and 12 months after discharge. Results One thousand thirteen of 2509 (40%) of adults and 360 of 849 (42%) of children discharged participated in both the 6- and 12-month follow-ups. PCC prevalence was 50% (95% CI 47–53) in adults and 20% (95% CI 16–24) in children at 6 months, with decline to 34% (95% CI 31–37) and 11% (95% CI 8–14), respectively, at 12 months. In adults, female sex was associated with PCC at 6- and 12-month follow-up (OR 2.04, 95% CI 1.57 to 2.65) and (OR 2.04, 1.54 to 2.69), respectively. Pre-existing hypertension (OR 1.42, 1.04 to 1.94) was associated with post-COVID-19 condition at 12 months. In children, neurological comorbidities were associated with PCC both at 6 months (OR 4.38, 1.36 to 15.67) and 12 months (OR 8.96, 2.55 to 34.82) while allergic respiratory diseases were associated at 12 months (OR 2.66, 1.04 to 6.47). Conclusions Although prevalence of PCC declined one year after discharge, one in three adults and one in ten children experienced ongoing sequelae. In adults, females and persons with pre-existing hypertension, and in children, persons with neurological comorbidities or allergic respiratory diseases are at higher risk of PCC.

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