Prevalence and prognostic significance of malnutrition in diabetic patients with coronary artery disease: a cohort study

Nutrition & Metabolism - Tập 18 - Trang 1-10 - 2021
Wen Wei1,2,3, Lingyu Zhang4, Guode Li4, Zhidong Huang1, Jin Liu1, Zhihuang Wu5, Yuanying Wu6, Jinrong Lin5, Yunhan Zhang7, Yaren Yu8, Haozhang Huang3, Qiang Li1, Bo Wang1, Yong Liu1,3,9, Mei Tu2, Hong Chen3,10, Shiqun Chen1
1Department of Cardiology, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
2Department of Endocrinology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, China
3The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China
4Department of Cardiology, Maoming People’s Hospital, Maoming, China
5School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, China
6Guangdong Medical University, Dongguan, China
7Kunming Medical University, Kunming, China
8Department of Cardiology, The First People’s Hospital of Foshan, Foshan, China
9Guangdong Provincial People’s Hospital, School of Medicine, South China University of Technology, Guangzhou, China
10Department of Endocrinology, Zhujiang Hospital, Southern Medical University, The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China

Tóm tắt

Malnutrition is associated with poor prognosis in cardiovascular disease patients or in diabetic patients. However, the relationship between malnutrition and clinical outcomes in diabetic patients with coronary artery disease (CAD) is not well known. The aim of this study is to report the prevalence and prognostic consequences of malnutrition in diabetic patients with CAD. In this retrospective observational study, the Controlling Nutritional Status (CONUT) score applied to 12,898 consecutive diabetic patients with CAD. The association between malnutrition and long-term all-cause mortality was examined using Cox proportional hazards regression analysis. According to CONUT score, 60.5% patients suffered from malnutrition; 46.4%, 13.2%, and 0.9% patients had mild, moderate, and severe malnutrition, respectively. During a median follow-up of 4.88 (2.83–7.51) years, 1973 (15.3%) patients died. After adjustment for confounders, malnutrition was associated with significantly increased risk for long-term all-cause mortality (adjusted hazard ratio for mild malnutrition and moderate to severe malnutrition, respectively: 1.38 [95% confidence interval (CI) 1.07–1.77]; P value = 0.012 and 1.63 [95% CI 1.18–2.24]; P value = 0.003). A similar association was observed around subgroups. Malnutrition is common in diabetic patients with CAD and is strongly associated with increased mortality. It is necessary to adequately assess the nutritional status and take the effective nutritional guidance to improve the prognosis of diabetic patients with CAD.

Tài liệu tham khảo

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Nutrition & Metabolism

Tập 18

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