Prevalence and incidence of clinically diagnosed Alzheimer's disease dementia from 1994 to 2012 in a population study

Alzheimer's & Dementia - Tập 15 - Trang 1-7 - 2019
Kumar B. Rajan1, Jennifer Weuve2, Lisa L. Barnes3, Robert S. Wilson3, Denis A. Evans4
1Department of Public Health Sciences, UC Davis, Davis, CA, USA
2Boston University School of Public Health, Department of Epidemiology, Boston, MA, USA
3Rush Alzheimer’s Disease Center, Chicago, IL, USA
4Rush Institute for Healthy Aging, Chicago, IL, USA

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AbstractIntroductionThe trends in prevalence and incidence of Alzheimer's disease (AD) dementia remain uncertain.MethodsA sample of 2794 participants with a clinical diagnosis for AD dementia were included.ResultsThe 2010 census standardized prevalence of AD dementia was 14.5% (95% CI = 13.7–15.3), and annual incidence was 2.3% (1.7–2.9). Both prevalence and incidence showed substantial variation over time, but no secular trends. The prevalence of AD dementia did not change significantly from 14.6% (95% CI = 13.0, 16.2) in 1994–1997 to 14.7% (95% CI = 13.2, 16.2) in 2010–2012 (P = .84). The annual incidence of AD dementia was 2.8% (95% CI = 2.2, 3.2) in 1998–2000 and 2.2% (95% CI = 1.6, 2.8) in 2004–2006 (P = .20) and remained steady in 2010–2012. The prevalence and incidence among African Americans were approximately twice than those among European Americans.ConclusionsThe prevalence and incidence of AD dementia showed substantial variation between 1994 and 2012, but no secular trend.

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Alzheimer's & Dementia

Tập 15

1-7

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