Prevalence, Mechanisms, and Implications of Gastrointestinal Symptoms in COVID-19

Abhilash Perisetti1, Hemant Goyal2,3, Mahesh Gajendran4, Umesha Boregowda5, Rupinder Mann6, Neil Sharma7,8
1Department of Gastroenterology and Hepatology, University of Arkansas for Medical Sciences, Little Rock, AR, United States
2Department of Internal Medicine, Mercer University School of Medicine, Macon, GA, United States
3The Wright Center for Graduate Medical Education, Scranton, PA, United States
4Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, TX, United States
5Department of Internal Medicine, Bassett Medical Center, Cooperstown, NY, United States
6Saint Agnes Medical Center, Academic Hospitalists, Fresno, CA, United States
7Division of Interventional Oncology and Surgical Endoscopy (IOSE), Parkview Cancer Institute, Fort Wayne, IN, United States
8Division of Interventional Oncology and Surgical Endoscopy, Indiana University School of Medicine, Fort Wayne, IN, United States

Tóm tắt

Từ khóa


Tài liệu tham khảo

Huang, 2020, Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China, Lancet., 395, 497, 10.1016/S0140-6736(20)30183-5

Coronavirus Update (Live):14,427,731 Cases and 604,963 Deaths from COVID-19 Virus Pandemic—Worldometer2020

Symptoms of Coronavirus CDC: @CDCgov2020

Johnson, 2020, Pulmonary and extra-pulmonary clinical manifestations of COVID-19, Front Med., 7, 526, 10.3389/fmed.2020.00526

Kopel, 2020, Clinical insights into the gastrointestinal manifestations of COVID-19, Dig Dis Sci., 65, 1932, 10.1007/s10620-020-06362-8

Ramachandran, 2020, Gastrointestinal symptoms and outcomes in hospitalized COVID-19 patients, Dig Dis, 38, 373, 10.1159/000509774

Randazzo, 2020, SARS-CoV-2 RNA in wastewater anticipated COVID-19 occurrence in a low prevalence area, Water Res., 181, 115942, 10.1016/j.watres.2020.115942

Fang, 2020, Manifestations of digestive system in hospitalized patients with novel coronavirus pneumonia in Wuhan, China: a single-center, descriptive study, Chin J Dig., 40, 10.3760/cma.j.issn.0254-1432.2020.0005

Wang, 2020, Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus–infected pneumonia in Wuhan, China, JAMA., 323, 1061, 10.1001/jama.2020.1585

Chen, 2020, Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study, BMJ., 368, m1091, 10.1136/bmj.m1091

Sultan, 2020, AGA institute rapid review of the gastrointestinal and liver manifestations of COVID-19, meta-analysis of international data, and recommendations for the consultative management of patients with COVID-19, Gastroenterology, 159, 320, 10.1053/j.gastro.2020.05.001

Lin, 2020, Gastrointestinal symptoms of 95 cases with SARS-CoV-2 infection, Gut., 69, 997, 10.1136/gutjnl-2020-321013

Goyal, 2018, Cannabis in liver disorders: a friend or a foe?, Eur J Gastroenterol Hepatol., 30, 1283, 10.1097/MEG.0000000000001256

Dhar, 2020, Gut microbiota and Covid-19-possible link and implications, Virus Res, 285, 198018, 10.1016/j.virusres.2020.198018

Wu, 2020, Characteristics of ocular findings of patients with coronavirus disease 2019 (COVID-19) in Hubei Province, China, JAMA Ophthalmol., 138, 575, 10.1001/jamaophthalmol.2020.1291

Darnell, 2004, Inactivation of the coronavirus that induces severe acute respiratory syndrome, SARS-CoV, J Virol Methods., 121, 85, 10.1016/j.jviromet.2004.06.006

Cavaliere, 2020, Management of upper GI bleeding in patients with COVID-19 pneumonia, Gastrointest Endosc., 92, 454, 10.1016/j.gie.2020.04.028

El-Kurdi, 2020, Mortality from covid-19 increases with unsaturated fat, and may be reduced by early calcium and albumin supplementation, Gastroenterology, 159, 1015, 10.1053/j.gastro.2020.05.057

Ramachandran, 2020, Prehospitalization proton pump inhibitor (PPI) use and clinical outcomes in COVID-19, medRxiv [Preprint]., 10.1101/2020.07.12.20151084

Dibner, 2020, Fecal-oral transmission of COVID-19: could hypochlorhydria play a role?, J Med Virol., 10.1002/jmv.26265

Zhang, 2020, Digestive system is a potential route of COVID-19: an analysis of single-cell coexpression pattern of key proteins in viral entry process, Gut., 69, 1010, 10.1136/gutjnl-2020-320953

Xiao, 2020, Evidence for gastrointestinal infection of SARS-CoV-2, Gastroenterology., 158, 1831, 10.1053/j.gastro.2020.02.055

Jose, 2020, COVID-19 cytokine storm: the interplay between inflammation and coagulation, Lancet Respir Med, 8, e46, 10.1016/S2213-2600(20)30216-2

Ramachandran, , Red blood cell distribution width (RDW) in hospitalized COVID-19 patients, medRxiv [Preprint]., 10.1101/2020.06.29.20143081

Sandhu, 2020, Clostridiodes difficile in COVID-19 patients, detroit, Michigan, USA, March-April 2020, Emerg Infect Dis., 26, 2272, 10.3201/eid2609.202126

Aziz, 2020, Taste changes (Dysgeusia) in COVID-19: a systematic review and metaanalysis, Gastroenterology, 159, 1132, 10.1053/j.gastro.2020.05.003

Nobel, 2020, Gastrointestinal symptoms and COVID-19: case-control study from the United States, Gastroenterology, 159, 373, 10.1053/j.gastro.2020.04.017

Cholankeril, 2020, High prevalence of concurrent gastrointestinal manifestations in patients with SARS-CoV-2: early experience from California, Gastroenterology, 159, 775, 10.1053/j.gastro.2020.04.008

Hajifathalian, 2020, Gastrointestinal and hepatic manifestations of 2019 novel coronavirus disease in a large cohort of infected patients from new york: clinical implications, Gastroenterology, 159, 1137, 10.1053/j.gastro.2020.05.010

Babic, 2014, The role of vagal neurocircuits in the regulation of nausea and vomiting, Eur J Pharmacol., 722, 38, 10.1016/j.ejphar.2013.08.047

Wei, 2020, Diarrhea is associated with prolonged symptoms and viral carriage in COVID-19, Clin Gastroenterol Hepatol., 18, 1753, 10.1016/j.cgh.2020.04.030

Cheung, 2020, Gastrointestinal manifestations of SARS-CoV-2 infection and virus load in fecal samples from a hong kong cohort: systematic review and meta-analysis, Gastroenterology, 159, 81, 10.1053/j.gastro.2020.03.065

D'Amico, 2020, Diarrhea during COVID-19 infection: pathogenesis, epidemiology, prevention and management, Clin Gastroenterol Hepatol., 18, 1663, 10.1016/j.cgh.2020.04.001

Xu, 2020, Acute kidney injury at early stage as a negative prognostic indicator of patients with COVID-19: a hospital-based retrospective analysis, medRxiv [Preprint], 10.1101/2020.03.24.20042408

Perisetti, 2020, Putative mechanisms of diarrhea in COVID-19, Clin Gastroenterol Hepatol., 30780, 10.1016/j.cgh.2020.06.008

Luo, 2020, Don't overlook digestive symptoms in patients with 2019 novel coronavirus disease (COVID-19), Clin Gastroenterol Hepatol., 18, 1636, 10.1016/j.cgh.2020.03.043

Cabrero-Hernández, 2020, Severe SARS-CoV-2 infection in children with suspected acute abdomen: a case series from a tertiary hospital in Spain, Pediatr Infect Dis J., 39, e195, 10.1097/INF.0000000000002777

Aloysius, 2020, COVID-19 presenting as acute pancreatitis, Pancreatology., 20, 1026, 10.1016/j.pan.2020.05.003

McNabb-Baltar, 2020, Lipase elevation in patients with COVID-19, Am J Gastroenterol, 115, 1286, 10.14309/ajg.0000000000000732

Barlass, 2020, Marked elevation of lipase in covid-19 disease: a cohort study, Clin Transl Gastroenterol., 11, e00215, 10.14309/ctg.0000000000000215

Gadiparthi, 2020, Gastrointestinal bleeding in patients with severe SARS-CoV-2, Am J Gastroenterol., 115, 1283, 10.14309/ajg.0000000000000719

Perlot, 2013, ACE2–From the renin–angiotensin system to gut microbiota and malnutrition, Microb Infect., 15, 866, 10.1016/j.micinf.2013.08.003

Thabane, 2009, Post-infectious irritable bowel syndrome, World J Gastroenterol., 15, 3591, 10.3748/wjg.15.3591

Garg, 2020, Imbalance of the renin–angiotensin system may contribute to inflammation and fibrosis in IBD: a novel therapeutic target?, Gut., 69, 841, 10.1136/gutjnl-2019-318512

Effenberger, 2020, Faecal calprotectin indicates intestinal inflammation in COVID-19, Gut, 69, 1543, 10.1136/gutjnl-2020-321388

Ramig, 2004, Pathogenesis of intestinal and systemic rotavirus infection, J Virol., 78, 10213, 10.1128/JVI.78.19.10213-10220.2004

Pan, 2020, Clinical characteristics of COVID-19 patients with digestive symptoms in Hubei, China: a descriptive, cross-sectional, multicenter study, Am J Gastroenterol., 115, 766, 10.14309/ajg.0000000000000620

Henry, 2020, Gastrointestinal symptoms associated with severity of coronavirus disease 2019 (COVID-19): a pooled analysis, Intern Emerg Med., 15, 857, 10.1007/s11739-020-02329-9

Ramachandran, 2020, Increased serum aminotransferase activity and clinical outcomes in Coronavirus disease 2019, J Clin Exp Hepatol., 10.1016/j.jceh.2020.06.009

Boregowda, 2020, Serum activity of liver enzymes is associated with higher mortality in COVID-19: a systematic review and meta-analysis, Front Med., 7, 431, 10.3389/fmed.2020.00431

Wang, 2005, Concentration and detection of SARS coronavirus in sewage from Xiao Tang Shan Hospital and the 309th Hospital, J Virol Methods., 128, 156, 10.1016/j.jviromet.2005.03.022

Wölfel, 2020, Virological assessment of hospitalized patients with COVID-2019, Nature., 581, 7809, 10.1038/s41586-020-2196-x

Han, 2020, Digestive symptoms in COVID-19 patients with mild disease severity: clinical presentation, stool viral RNA testing, and outcomes, Am J Gastroenterol, 115, 916, 10.14309/ajg.0000000000000664

Ling, 2020, Persistence and clearance of viral RNA in 2019 novel coronavirus disease rehabilitation patients, Chin Med J., 133, 1039, 10.1097/CM9.0000000000000774

Dreher, 2020, Charakteristik von 50 hospitalisierten COVID-19-Patienten mit und ohne ARDS, Dtsch Arztebl Int., 117, 271, 10.3238/arztebl.2020.0271

Perisetti, 2019, Role of face mask in preventing bacterial exposure to the endoscopist's face, Gastrointest Endosc., 90, 859, 10.1016/j.gie.2019.06.016

Johnston, 2019, Risk of bacterial exposure to the endoscopist's face during endoscopy, Gastrointest Endosc., 89, 818, 10.1016/j.gie.2018.10.034

Rahman, 2019, Duodenoscope-associated infections: update on an emerging problem, Dig Dis Sci., 64, 1409, 10.1007/s10620-018-5431-7

Sawhney, 2020, Triaging advanced gi endoscopy procedures during the COVID-19 pandemic: consensus recommendations using the Delphi method, Gastrointest Endosc, 92, 535, 10.1016/j.gie.2020.05.014

Chiu, 2020, Practice of endoscopy during COVID-19 pandemic: position statements of the Asian Pacific society for digestive endoscopy (APSDE-COVID statements), Gut., 69, 991, 10.1136/gutjnl-2020-321185

Repici, 2020, Coronavirus (COVID-19) outbreak: what the department of endoscopy should know, Gastrointest Endosc, 92, 192, 10.1016/j.gie.2020.03.019

Kiedrowski, 2013, Disinfection of iPad to reduce contamination with Clostridium difficile and methicillin-resistant Staphylococcus aureus, Am J Infect Control, 41, 1136, 10.1016/j.ajic.2013.01.030

Repici, 2020, Low risk of covid-19 transmission in GI endoscopy, Gut, 69, 1925, 10.1136/gutjnl-2020-321341

Franzini, 2020, Approach to endoscopic procedures: a routine protocol from a quaternary University referral center exclusively for coronavirus disease 2019 patients, Clinics., 75, e1989, 10.6061/clinics/2020/e1989

Cennamo, 2020, Redesign of a GI endoscopy unit during the COVID-19 emergency: a practical model, Dig Liver Dis., 52, 1178, 10.1016/j.dld.2020.05.007

Corral, 2020, COVID-19 polymerase chain reaction testing before endoscopy: an economic analysis, Gastrointest Endosc, 92, 524, 10.1016/j.gie.2020.04.049

Pawlak, 2020, Impact of COVID-19 on endoscopy trainees: an international survey, Gastrointest Endosc, 92, 925, 10.1016/j.gie.2020.06.010

London, 2020, Effects of the COVID-19 pandemic on cancer-related patient encounters, JCO., 4, 657, 10.1200/CCI.20.00068

Cao, 2020, A trial of lopinavir–ritonavir in adults hospitalized with severe Covid-19, N Engl J Med, 82, 1787, 10.1056/NEJMoa2001282

Grein, 2020, Compassionate use of remdesivir for patients with severe Covid-19, New Engl J Med., 382, 2327, 10.1056/NEJMc2015312

Tang, 2020, Hydroxychloroquine in patients with mainly mild to moderate coronavirus disease 2019: open label, randomised controlled trial, bmj., 369, m1849, 10.1136/bmj.m1849

Boregowda, 2020, Addition of Tocilizumab to the standard of care reduces mortality in severe COVID-19: a systematic review and meta-analysis, medRxiv, 10.1101/2020.07.10.20150680

Aguila, 2020, Repurposed GI drugs in the treatment of COVID-19, Dig Dis Sci., 65, 1, 10.1007/s10620-020-06430-z

Almario, 2020, Increased risk of COVID-19 among users of proton pump inhibitors, Am J Gastroenterol., 115, 1707, 10.14309/ajg.0000000000000798