Preparation of a novel poloxamer hydrogel

Wiley - Tập 88 Số 11 - Trang 2670-2676 - 2003
HaeYong Kweon1, Mi‐Kyong Yoo1, Jin‐Hak Lee2, Won‐Ryang Wee2, Young‐Gun Han2, Kwang‐Gill Lee3, Chong‐Su Cho1
1School of Agricultural Biotechnology, Seoul National University, 103 Serdun-dong, Kwonseun-gu, Suwon 441-744, South Korea
2Department of Ophthalmology, Seoul National University College of Medicine, Seoul Artificial Eye Center, Seoul National University Hospital Clinical Research Institute, Seoul 110-799, South Korea
3Department of Sericulture and Entomology, National Institute of Agriculture and Technology, Suwon 441-100, South Korea.

Tóm tắt

AbstractPoloxamer hydrogels were prepared by photopolymerization from poloxamer macromer, which was synthesized by reaction of poloxamer 407 with acryloyl chloride. The synthesis of poloxamer macromer was confirmed using NMR and FTIR spectrometry. The gelation behavior and crystalline structure of poloxamer macromer was similar to those of poloxamer 407 itself; however, the amorphous scattering of poloxamer macromer was higher than that of poloxamer itself. Differential scanning calorimetric analysis showed that the melting temperature and enthalpy of poloxamer hydrogel were also lower than those of poloxamer itself. The compressive modulus of poloxamer hydrogels were similar (92.6–101.7 kPa), regardless of the concentration of poloxamer macromer. Equilibrium water uptake of poloxamer hydrogels decreased with an increase of concentration of poloxamer macromer. © 2003 Wiley Periodicals, Inc. J Appl Polym Sci 88: 2670–2676, 2003

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Tài liệu tham khảo

Ratner B. D., 1981, 146

10.1016/S0142-9612(98)00023-4

10.1016/S0376-7388(98)00097-0

10.1163/156856201753113114

10.1016/S0169-409X(01)00243-5

10.1016/S0169-409X(01)00239-3

Henry R. L., 1989, Crit Rev Biocompatibility, 5, 207

10.1023/A:1015887213431

10.1016/0378-5173(86)90182-1

10.1248/cpb.32.4205

10.1002/pola.1994.080320708

Cho C. S., 1994, Kor Polym J, 2, 91

10.1016/S0378-5173(99)00031-9

10.1002/app.1281

10.1006/jcis.1997.4880

10.1016/0927-7757(94)03028-X

10.1002/1521-3927(20001201)21:18<1302::AID-MARC1302>3.0.CO;2-6

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Wiley

Tập 88 Số 11

2670-2676

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