Pregnancy loss and risk of later dementia: A nationwide cohort study, Denmark, 1977–2017

Alzheimer's and Dementia: Translational Research and Clinical Interventions - Tập 5 - Trang 146-153 - 2019
Saima Basit1, Jan Wohlfahrt1, Heather A. Boyd1
1Department of Epidemiology Research, Statens Serum Institut, Copenhagen S, Denmark

Tóm tắt

AbstractIntroductionPregnancy losses may be associated with increased risks of dementia.MethodsWe conducted a register‐based cohort study in 1,243,957 women with ≥1 pregnancy in Denmark in the period 1977–2015. Using Cox regression, we estimated hazard ratios (HRs) comparing risks of dementia in women with and without pregnancy losses.ResultsDuring 21,672,433 person‐years of follow‐up, 261,279 women experienced a pregnancy loss, and 2188 women were diagnosed with dementia. Stillbirth was associated with an 86% increased risk of dementia overall (HR 1.86, 95% confidence interval [CI] 1.28–2.71). By contrast, miscarriage was not associated with later risk of dementia overall (single miscarriage, HR 0.99, 95% CI 0.87–1.12; recurrent miscarriages, HR 1.06, 95% CI 0.84–1.35). Adjustment for cardiovascular disease, hypertension, and diabetes did not meaningfully alter the association magnitudes.DiscussionStillbirth and dementia may share underlying mechanisms, suggesting that a history of stillbirth should be considered when assessing dementia risk in women.

Tài liệu tham khảo

M.Prince A.Wimo M.Guerchet A.Gemma‐Claire Y.‐T.Wu andM.Prina.World Alzheimer Report 2015: The global impact of dementia ‐ An analysis of prevalence incidence cost and trends.Alzheimer's Dis Int 2015;84 10.1016/j.trci.2015.08.003 10.1016/j.jalz.2015.05.016 10.1016/j.maturitas.2014.05.008 10.1089/jwh.2012.3789 10.31887/DCNS.2016.18.4/cepperson 10.1136/bmj.k4109 10.1212/WNL.0000000000006000 10.1161/CIRCULATIONAHA.112.000285 10.1007/s10654-012-9683-9 Meyer J.S., 2000, Cardiovascular and other risk factors for Alzheimer's disease and vascular dementia, Vasc Factors Alzheimer's Dis, 903, 411 10.1016/j.jalz.2014.05.1758 10.1111/jdi.12087 10.1007/s10654-014-9930-3 Knudsen L.B., 1998, The Danish Medical Birth Registry, Dan Med Bull, 45, 320 10.1177/1403494811401482 10.1177/1403494811399958 10.1177/1403494810394717 10.1093/aje/kwp107 10.1093/biomet/80.3.557 10.1002/pds.1200 10.1111/ppe.12142 10.2174/156720507780362047 10.1111/j.1467-789X.2010.00825.x 10.1001/archneurol.2008.582 10.1371/journal.pone.0118333 10.1111/1471-0528.12694 10.1370/afm.1668 10.1136/heartjnl-2012-303237 10.1186/s12916-014-0206-2 10.1373/clinchem.2007.097469 10.1001/archneur.55.11.1449 Goldacre M.J., 2017, Associations between specific autoimmune diseases and subsequent dementia: Retrospective record‐linkage cohort study, UK, J Epidemiol Community Health, 71, 576, 10.1136/jech-2016-207809 10.1007/s10815-013-0128-5 Rohn T.T., 2014, Is apolipoprotein E4 an important risk factor for vascular dementia?, Int J Clin Exp Pathol, 7, 3504 10.1111/ppe.12176 10.1016/S0140-6736(15)00836-3 10.1038/nrneurol.2011.60 10.1016/j.maturitas.2014.05.009 10.1016/j.jalz.2016.07.152 10.1159/000269933 10.1159/000107084 10.1017/cjn.2016.18 10.2174/1745017901309010088 10.1186/1471-2458-14-643 10.1177/14034948990270021301 10.1007/s10654-016-0190-2 10.1093/ageing/afp094
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Alzheimer's and Dementia: Translational Research and Clinical Interventions

Tập 5

146-153

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