Predictors of Impaired Postpartum Renal Function in Women after Preeclampsia: Results of a Prospective Single Center Study

Disease Markers - Tập 2016 - Trang 1-8 - 2016
T Kaleta1, Anke Stock1, Dimitrios Panayotopoulos2, Oliver Vonend3, Dieter Niederacher1, Mark A. Neumann1, Tanja Fehm1, Wolfgang Kaisers4, Markus C. Fleisch5
1Department of Obstetrics and Gynaecology, Heinrich-Heine-University Medical Centre, Moorenstrasse 5, 40225 Duesseldorf, Germany
2Department of Obstetrics and Gynecology, Dormagen Hospital, Dr.-Geldmacher-Straße 20, 41540 Dormagen, Germany
3Department of Nephrology, DKD Helios Clinic Wiesbaden GbR, Aukammallee 33, 65191 Wiesbaden, Germany
4Department of Mathematics, Faculty of Mathematics and Natural Sciences, Heinrich-Heine-University, Universitätsstrasse 1, 40225 Düsseldorf, Germany
5Department of Obstetrics and Gynaecology, Helios University Medical Center Wuppertal, Heusnerstraße 40, 42283 Wuppertal, Germany

Tóm tắt

Objective. The purpose of this prospective study was to investigate the predictive value of single prepartum findings combined with serum biomarkers sFlt-1 (soluble fms-like tyrosine kinase-1) and PlGF (placental growth factor) indicating severity of preeclampsia (PE) for occurrence and extent of impaired postpartum kidney function.Study Design. In this prospective, single center study 44 PE patients were compared to 39 healthy controls (similar in age and gestational age with singleton pregnancy) evaluated at time of delivery and at 6 months and 12 months postpartum.pvalues below 0.05 are considered statistically significant.Results. The majority of the PE patients had persistence of proteinuria (>120 mg/L after delivery) 6 months (p=0.02) and 12 months postpartum (p<0.0001) compared to controls. Also reduced GFR (glomerular filtration rate) persisted up to 6 months postpartum in PE patients compared to controls (p<0.001). Prepartum sFlt-1 levels indeed correlated with impaired renal function parameters.Conclusion. A significant proportion of our PE patients had lower GFR levels and persistent proteinuria up to 12 months postpartum. Prepartum sFlt-1 is a trend-setting marker for impaired renal function postpartum, but it is not sufficient enough to predict renal impairment after PE. An evaluation of 24-month follow-up data is scheduled.

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Disease Markers

Tập 2016

1-8

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