Postoperative hypoxemia and hypercarbia in healthy dogs undergoing routine ovariohysterectomy or castration and receiving butorphanol or hydromorphone for analgesia

Journal of the American Veterinary Medical Association - Tập 222 Số 3 - Trang 330-336 - 2003
Vicki L. Campbell1, Kenneth J. Drobatz, Sandra Z. Perkowski
1Section of Anesthesia and Critical Care, Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Tóm tắt

AbstractObjective—To determine frequency and severity of postanesthetic hypoxemia and hypercarbia in healthy dogs undergoing elective ovariohysterectomy or castration and given butorphanol or hydromorphone for analgesia.Design—Prospective trial.Animals—20 healthy dogs weighing > 10 kg (22 lb).Procedure—Dogs were anesthestized with acepromazine, glycopyrrolate, thiopental, and isoflurane, and butorphanol (n = 10) or hydromorphone (10) was used for perioperative analgesia. Arterial blood gas analyses were performed 10 and 30 minutes and 1, 2, 3, and 4 hours after extubation.Results—In dogs that received hydromorphone, mean PaCO2was significantly higher, compared with the preoperative value, 10 and 30 minutes and 1, 2, and 3 hours after extubation. Mean PaCO2was significantly higher in dogs given hydromorphone rather than butorphanol 10 and 30 minutes and 1 and 2 hours after extubation. Mean PaO2was significantly lower, compared with preoperative values, 30 minutes and 1 and 2 hours after extubation in dogs given hydromorphone and 30 minutes after extubation in dogs given butorphanol. Mean PaO2was significantly lower in dogs given hydromorphone rather than butorphanol 1 hour after extubation. Four dogs had PaO2< 80 mm Hg 1 or more times after extubation.Conclusions and Clinical Relevance—Results suggest that administration of hydromorphone to healthy dogs undergoing elective ovariohysterectomy or castration may result in transient increases in PaCO2postoperatively and that administration of hydromorphone or butorphanol may result in transient decreases in PaO2. However, increases in PaCO2and decreases in PaO2were mild, and mean PaCO2and PaO2remained within reference limits. (J Am Vet Med Assoc2003;222:330–336)

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Journal of the American Veterinary Medical Association

Tập 222 Số 3

330-336

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