Postnatal development of uridine diphosphate glucuronyltransferase activity towards bilirubin and 2-aminophenol in human liver

Biochemical Journal - Tập 184 Số 3 - Trang 705-707 - 1979
S Onishi1, N Kawade1, Shinji Itoh1, Kimiyasu Isobe1, S Sugiyama1
1Department ofPediatrics, Nagoya City University Medical School, Kawasumi Mizuho-ku, Nagoya, Japan

Tóm tắt

UDP-glucuronyltransferase activities towards 2-aminophenol and bilirubin were studied in a total of 70 human subjects, including premature and full-term newborn babies, infants, children and adults. These two activities have been reported in rat to develop latefoetally and neonatally respectively, but in man they both develop neonatally. There is a linear relationship between the logarithm of each liver transferase activity and the logarithm of the number of days after birth during the first 3 months of life, after which each activity remains constant.

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