Post-intensive care syndrome (PICS): recent updates

Springer Science and Business Media LLC - Tập 11 - Trang 1-10 - 2023
Stephanie L. Hiser1,2,3, Arooj Fatima3,4, Mazin Ali3,4, Dale M. Needham2,3,4,5
1Department of Health, Human Function, and Rehabilitation Sciences, The George Washington University, Washington, USA
2Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, USA
3Outcomes After Critical Illness and Surgery (OACIS) Group, Johns Hopkins University, Baltimore, USA
4Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, USA
5School of Nursing, Johns Hopkins University, Baltimore, USA

Tóm tắt

An increasing number of patients are surviving critical illness, but some experience new or worsening long-lasting impairments in physical, cognitive and/or mental health, commonly known as post-intensive care syndrome (PICS). The need to better understand and improve PICS has resulted in a growing body of literature exploring its various facets. This narrative review will focus on recent studies evaluating various aspects of PICS, including co-occurrence of specific impairments, subtypes/phenotypes, risk factors/mechanisms, and interventions. In addition, we highlight new aspects of PICS, including long-term fatigue, pain, and unemployment.

Tài liệu tham khảo

Calvin JE, Habet K, Parrillo JE. Critical care in the United States who are we and how did we get here? Crit Care Clin. 1997;13(2):363–76. https://doi.org/10.1016/s0749-0704(05)70315-8. Efu ME, Ojo B, Eke BA, Anefu GO, Ozoagu MA. Characterization of the intensive care unit (ICU) admission in the Benue State University teaching hospital. Med Surg Sci. 2019;6(4):126–8. https://doi.org/10.32457/ijmss.2019.037.Efu. Kaukonen K, Bailey M, Suzuki S, Pilcher D, Bellomo R. Mortality related to severe sepsis and septic shock among critically ill patients in Australia and New Zealand, 2000–2012. JAMA. 2014;311(13):1308–16. https://doi.org/10.1001/jama.2014.2637. Needham DM, Davidson J, Cohen H, et al. Improving long-term outcomes after discharge from intensive care unit. Crit Care Med. 2012;40(2):502–9. https://doi.org/10.1097/CCM.0b013e318232da75. Neufeld KJ, Leoutsakos JS, Yan H, et al. Fatigue symptoms during the first year following ARDS. Chest. 2020;158(3):999–1007. https://doi.org/10.1016/j.chest.2020.03.059. Geense WW, Zegers M, Peters MAA, et al. New physical, mental, and cognitive problems 1 year after ICU admission. Am J Respir Crit Care Med. 2021;203(12):1512–21. https://doi.org/10.1164/rccm.202009-3381OC. Griffiths J, Hatch RA, Bishop J, et al. An exploration of social and economic outcome and associated health-related quality of life after critical illness in general intensive care unit survivors : a 12-month follow-up study. Crit Care. 2013;17(3):R100. https://doi.org/10.1186/cc12745. Knowles RE, Tarrier N. Evaluation of the effect of prospective patient diaries on emotional well-being in intensive care unit survivors: a randomized controlled trial. Crit Care Med. 2009;37(1):184–91. https://doi.org/10.1097/CCM.0b013e31819287f7. Azoulay E, Vincent J, Angus DC, et al. Recovery after critical illness: putting the puzzle together—a consensus of 29. Crit Care. 2017;21(1):296. https://doi.org/10.1186/s13054-017-1887-7. Spragg RG, Bernard GR, Checkley W, et al. Beyond mortality: future clinical research in acute lung injury. Am J Respir Crit Care Med. 2010;181(10):1121–7. https://doi.org/10.1164/rccm.201001-0024WS. Needham DM, Sepulveda KA, Dinglas VD, et al. Core outcome measures for clinical research in acute respiratory failure survivors an international modified Delphi consensus study. Crit Care Med. 2017;196(9):1122–30. https://doi.org/10.1164/rccm.201702-0372OC. Brown SM, Wilson EL, Presson AP, et al. Understanding patient outcomes after acute respiratory distress syndrome: identifying subtypes of physical, cognitive and mental health outcomes. Thorax. 2017;72(12):1094–103. https://doi.org/10.1136/thoraxjnl-2017-210337. The PHOSP-COVID Collaborative Group. Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK : a prospective observational study. Lancet Respir Med. 2022;2600(22):1–15. https://doi.org/10.1016/S2213-2600(22)00127-8. Heesakkers H, van der Hoeven J, Corsten S, et al. Clinical outcomes among patients with 1-year survival following intensive care unit treatment for COVID-19. JAMA. 2022;327(6):559–65. https://doi.org/10.1001/jama.2022.0040. Parker A. Behavioral activation-rehabilitation to improve depressive symptoms and physical function after acute respiratory failure (BEHAB). 2022:1-9. https://clinicaltrials.gov/ct2/show/study/NCT03431493. Lee M, Kang J, Jeong Y. Risk factors for post-intensive care syndrome: a systematic review and meta-analysis. Aust Crit Care. 2020;33(3):287–94. https://doi.org/10.1016/j.aucc.2019.10.004. Cabrini L, Landoni G, Antonelli M, et al. Critical care in the near future: patient-centered, beyond space and time boundaries. Ninerva Anestesiol. 2016;82(5):599–604. Hashem M, Hopkins R, Colantuoni E, et al. Six-month and 12-month patient outcomes based on inflammatory subphenotypes in sepsis-associated ARDS: secondary analysis of SAILS-ALTOS trial. Thorax. 2022;77:22–30. https://doi.org/10.1136/thoraxjnl-2020-216613. Brummel NE, Hughes CG, Thompson JL, et al. Inflammation and coagulation during critical illness and long-term cognitive impairment and disability. Am J Respir Crit Care Med. 2021;203(6):699–706. https://doi.org/10.1164/rccm.201912-2449OC. Parker A, Sinha P, Needham D. Biological mechanisms of cognitive and physical impairments after critical care rethinking the inflammatory model? Am J Respir Crit Care Med. 2021;203(6):665–7. https://doi.org/10.1164/rccm.202010-3896ED. Geense W, van den Boogaard M, van der Hoeven J, Vermuelen H, Hannink G, Zegers M. Nonpharmacologic interventions to prevent or mitigate adverse long-term outcomes among ICU survivors: a systematic review and meta-analysis. Crit Care Med. 2019;47(11):1607–18. https://doi.org/10.1097/CCM.0000000000003974. Chen S, Su CL, Wu YT, et al. Physical training is beneficial to functional status and survival in patients with prolonged mechanical ventilation. J Formos Med Assoc. 2011;110(9):572–9. https://doi.org/10.1016/j.jfma.2011.07.008. Vitacca M, Barbano L, Vanoglio F, et al. Does 6-month home caregiver-supervised physiotherapy improve post-critical care outcomes? Am J Phys Med Rehabil. 2016;95(8):571–9. https://doi.org/10.1097/PHM.0000000000000441. Brummel NE, Girard TD, Ely EW, et al. Feasibility and safety of early combined cognitive and physical therapy for critically ill medical and surgical patients: the activity and cognitive therapy in ICU (ACT-ICU) trial. Intensive Care Med. 2014;40(3):370–9. https://doi.org/10.1007/s00134-013-3136-0. Jones C, Skirrow P, Griffiths RD, et al. Rehabilitation after critical illness: a randomized, controlled trial. Crit Care Med. 2003;31(10):2456–61. https://doi.org/10.1097/01.CCM.0000089938.56725.33. Battle C, James K, Temblett P, Hutchings H. Supervised exercise rehabilitation in survivors of critical illness: a randomised controlled trial. J Intensive Care Soc. 2019;20(1):18–26. https://doi.org/10.1177/1751143718767061. Shelly A, Prabhu N, Jirange P, Kamath A, Vaishali K. Quality of life improves with individualized home-based exercises in critical care survivors. Indian J Crit Care Med. 2017;21(2):89–93. https://doi.org/10.4103/ijccm.IJCCM_433_16. McDowell K, O’Neill B, Blackwood B, et al. Effectiveness of an exercise programme on physical function in patients discharged from hospital following critical illness: a randomised controlled trial (the REVIVE trial). Thorax. 2016;72(7):600–9. https://doi.org/10.1136/thoraxjnl-2016-208723. McWilliams DJ, Benington S, Atkinson D. Outpatient-based physical rehabilitation for survivors of prolonged critical illness: a randomized controlled trial. Physiother Theory Pract. 2016;32(3):179–90. https://doi.org/10.3109/09593985.2015.1137663. Connolly B, Thompson A, Douiri A, Moxham J, Hart N. Exercise-based rehabilitation after hospital discharge for survivors of critical illness with intensive care unit-acquired weakness: a pilot feasibility trial. J Crit Care. 2015;30(3):589–98. https://doi.org/10.1016/j.jcrc.2015.02.002. Batterham AM, Bonner S, Wright J, Howell SJ, Hugill K, Danjoux G. Effect of supervised aerobic exercise rehabilitation on physical fitness and quality-of-life in survivors of critical illness: an exploratory minimized controlled trial (PIX study). Br J Anaesth. 2014;113(1):130–7. https://doi.org/10.1093/bja/aeu051. Arthur HM, Daniels C, McKelvie R, Hirsh J, Rush B. Effect of a preoperative intervention on preoperative and postoperative outcomes in low-risk patients awaiting elective coronary artery bypass graft surgery: a randomized, controlled trial. Ann Intern Med. 2000;133(4):253–62. https://doi.org/10.7326/0003-4819-133-4-200008150-00007. Jackson J, Ely W, Morey M, et al. Cognitive and physical rehabilitation of ICU survivors: results of the RETURN randomized, controlled pilot investigation. Crit Care Med. 2012;40(4):1088–97. https://doi.org/10.1097/CCM.0b013e3182373115. Elliott D, McKinley S, Alison J, et al. Health-related quality of life and physical recovery after a critical illness: a multi-centre randomised controlled trial of a home-based physical rehabilitation program. Crit Care. 2011;15(3):R142. https://doi.org/10.1186/cc10265. Jónasdóttir RJ, Jónsdóttir H, Gudmundsdottir B, Sigurdsson GH. Psychological recovery after intensive care: outcomes of a long-term quasi-experimental study of structured nurse-led follow-up. Intensive Crit Care Nurs. 2018;44:59–66. https://doi.org/10.1016/j.iccn.2017.06.001. Jensen JF, Egerod I, Bestle MH, et al. A recovery program to improve quality of life, sense of coherence and psychological health in ICU survivors: a multicenter randomized controlled trial, the RAPIT study. Intensive Care Med. 2016;42(11):1733–43. https://doi.org/10.1007/s00134-016-4522-1. Schmidt K, Worrack S, Korff M, et al. Effect of a primary care management intervention on mental-health-related quality of life among survivors of sepsis: a randomized clinical trial. JAMA. 2016;315(24):2703–11. https://doi.org/10.1053/j.gastro.2016.08.014.CagY. Cuthbertson BH, Rattray J, Campbell MK, et al. The PRaCTICaL study of nurse led, intensive care follow-up programmes for improving long term outcomes from critical illness: a pragmatic randomised controlled trial. BMJ. 2009;339(7728):1016. https://doi.org/10.1136/bmj.b3723. Douglas S, Daly B, Kelley C, O’Toole E, Montenegro H. Chronically critically ill patients: health-related quality of life and resource use after a disease management intervention. Am J Crit Care. 2007;16(5):447–57. Cox CE, Hough CL, Jones DM, et al. Effects of mindfulness training programmes delivered by a self-directed mobile app and by telephone compared with an education programme for survivors of critical illness: a pilot randomised clinical trial. Thorax. 2019;74(1):33–42. https://doi.org/10.1136/thoraxjnl-2017-211264. Cox CE, Hough CL, Carson SS, et al. Effects of a telephone- and web-based coping skills training program compared with an education program for survivors of critical illness and their family members a randomized clinical trial. Am J Respor Crit Care Med. 2018;197(1):66–78. https://doi.org/10.1164/rccm.201704-0720OC. Ågren S, Berg S, Svedjeholm R, Strömberg A. Psychoeducational support to post cardiac surgery heart failure patients and their partners—a randomised pilot study. Intensive Crit Care Nurs. 2015;31(1):10–8. https://doi.org/10.1016/j.iccn.2014.04.005. Wright SE, Thomas K, Watson G, et al. Intensive versus standard physical rehabilitation therapy in the critically ill (EPICC): a multicentre, parallel-group, randomised controlled trial. Thorax. 2018;73(3):213–21. https://doi.org/10.1136/thoraxjnl-2016-209858. Garrouste-Orgeas M, Coquet I, Perier A, et al. Impact of an intensive care unit diary on psychological distress in patients and relatives. Crit Care Med. 2012;40:2033–40. https://doi.org/10.1097/CCM.0b013e31824e1b43. Jones C, Bäckman C, Capuzzo M, et al. Intensive care diaries reduce new onset post traumatic stress disorder following critical illness: a randomised, controlled trial. Crit Care. 2010;14(5):R168. https://doi.org/10.1186/cc9260. Demircelik MB, Cakmak M, Nazli Y, et al. Effects of multimedia nursing education on disease-related depression and anxiety in patients staying in a coronary intensive care unit. Appl Nurs Res. 2016;29:5–8. https://doi.org/10.1016/j.apnr.2015.03.014. Fleischer S, Berg A, Behrens J, et al. Does an additional structured information program during the intensive care unit stay reduce anxiety in ICU patients ?: a multicenter randomized controlled trial. BMC Anesthesiol. 2014;14(1):1–11. https://doi.org/10.1186/1471-2253-14-48. Sosnowski K, Mitchell ML, White H, et al. A feasibility study of a randomised controlled trial to examine the impact of the ABCDE bundle on quality of life in ICU survivors. Pilot Feasibility Stud. 2018;4(1):1–12. https://doi.org/10.1186/s40814-017-0224-x. Demoule A, Carreira S, Lavault S, et al. Impact of earplugs and eye mask on sleep in critically ill patients : a prospective randomized study. Crit Care. 2017;21:284. https://doi.org/10.1186/s13054-017-1865-0. Giraud K, Pontin M, Sharples LD, et al. Use of a structured mirrors intervention does not reduce delirium incidence but may improve factual memory encoding in cardiac surgical ICU patients aged over 70 years : a pilot time-cluster randomized controlled trial. Front Aging Neurosci. 2016;8:228. https://doi.org/10.3389/fnagi.2016.00228. Morris PE, Berry MJ, Files DC, et al. Standardized rehabilitation and hospital length of stay among patients with acute respiratory failure a randomized clinical trial. JAMA. 2016;315(24):2694–702. https://doi.org/10.1001/jama.2016.7201. Hodgson CL, Bailey M, Bellomo R, et al. A binational multicenter pilot feasibility randomized controlled trial of early goal-directed mobilization in the ICU. Crit Care Med. 2016;44(6):1145–52. https://doi.org/10.1097/CCM.0000000000001643. Schaller SJ, Anstey M, Blobner M, et al. Early, goal-directed mobilisation in the surgical intensive care unit: a randomised controlled trial. Lancet. 2016;388(10052):1377–88. https://doi.org/10.1016/S0140-6736(16)31637-3. Kayambu G, Boots R, Paratz J. Early physical rehabilitation in intensive care patients with sepsis syndromes: a pilot randomised controlled trial. Intensive Care Med. 2015;41(5):865–74. https://doi.org/10.1007/s00134-015-3763-8. Moss M, Nordon-Craft A, Malone D, et al. A randomized trial of an intensive physical therapy program for patients with acute respiratory failure. Am J Respir Crit Care Med. 2016;193(10):1101–10. https://doi.org/10.1164/rccm.201505-1039OC. Denehy L, Skinner EH, Edbrooke L, et al. Exercise rehabilitation for patients with critical illness: a randomized controlled trial with 12 months of follow-up. Crit Care. 2013;17(4):1–12. https://doi.org/10.1186/cc12835. Probert JM, Lin S, Yan H, et al. Bodily pain in survivors of acute respiratory distress syndrome : a 1-year longitudinal follow-up study. J Psychosom Res. 2021;144:110418. https://doi.org/10.1016/j.jpsychores.2021.110418. Hayhurst CJ, Jackson JC, Archer KR, Thompson JL, Chandrasekhar R, Hughes CG. Pain and its long-term interference of daily life after critical illness. Anesth Analg. 2018;127(3):690–7. https://doi.org/10.1213/ANE.0000000000003358. Herridge MS, Cheung AM, Tansey CM, et al. One-year outcomes in survivors of the acute respiratory distress syndrome. N Engl J Med. 2003;348(8):683–93. Kamdar BB, Suri R, Suchyta MR, et al. Return to work after critical illness : a systematic review and meta-analysis. Thorax. 2020;75(1):17–27. https://doi.org/10.1136/thoraxjnl-2019-213803. Su H, Thompson HJ, May S, et al. Association of job characteristics and functional impairments on return to work after ARDS. Chest. 2021;160(2):509–18. https://doi.org/10.1016/j.chest.2021.03.008. Su H, Hopkins RO, Kamdar BB, et al. Association of imbalance between job workload and functional ability with return to work in ARDS survivors. Thorax. 2022;77(2):123–8. https://doi.org/10.1136/thoraxjnl-2020-216586. Su H, Thompson HJ, Pike K, et al. Interrelationships among workload, illness severity, and function on return to work following acute respiratory distress syndrome. Aust Crit Care. 2023;36(2):247–53. https://doi.org/10.1016/j.aucc.2022.01.002.