Possible interaction of platelets and adrenaline in the early phase of myocardial infarction
Tóm tắt
It is known that in most cases of transmural acute myocardial infarction a platelet clot originates within a coronary artery. In acute myocardial infarction patients increased levels of the plasma catecholamines adrenaline and noradrenaline as well as the platelet release proteins platelet factor 4 andβ-thromboglobulin have been reported. In this study, significantly higher values were found of platelet factor 4 (P < 0.0001) andβ-thromboglobulin (P < 0.002) in 17 acute myocardial infarction patients as compared to 17 control patients (on intensive care due to non-cardiac disorders), while the plasma levels of adrenaline and noradrenaline were not different. Positive correlations were obtained between the two catecholamines and the platelet products in the control group and between adrenaline and both platelet factor 4 (r = 0.715,P < 0.01) andβ-thromboglobulin (r = 0.547,P < 0.05) in the acute myocardial infarction patients. The data suggest that a stimulation of the platelets by adrenaline may facilitate in vitro activation during sampling in patients with high catecholamine load. On the other hand, a “preactivation” of the platelets by an increase of adrenaline might be of significance for thrombus formation in acute myocardial infarction.
Tài liệu tham khảo
Oliva PD (1981) Pathophysiology of acute myocardial infarction. Ann Int Med 94:236–250
El-Maraghi N, Genton E (1980) The relevance of platelet and fibrin thromboembolism of the coronary microcirculation, with special reference to sudden cardiac death. Circulation 62:936–944
Meade TW, North WRS, Chakrabarti R, Stirling Y, Haines AP, Thompson SG (1980) Haemostatic function and cardiovascular death: Early results of a prospective study. Lancet 1:1050–1053
Reimers H-J (1981) Die Rolle der Thrombozyten in der Pathogenese der Koronarthrombose. Hämostaseologie 1:13–19
Haft JI (1979) Role of blood platelets in coronary artery disease. Am J Cardiol 43:1197–1206
Heptinstall S, Mulley GP, Taylor PM, Mitchell JRA (1980) Platelet-release reaction in myocardial infarction. Br Med J 1:80–81
Neri Sereni GG, Abate R, Gensini GF, Galanti G, Paoli G, Laureano R (1982) Platelet aggregation and thromboxane A2 production after adrenergic stimulation in young healthy humans. Haemostasis 11:40–48
Haft JI, Fani K (1973) Intravascular platelet aggregation in the heart induced by stress. Circulation 47:353–358
Da Prada M, Picotti GB (1979) Content and subcellular localization of catecholamines and 5-hydroxytryptamine in human and animal blood platelets: Monoamine distribution between platelets and plasma. Br J Pharmacol 65:653–662
Videbaek J, Christensen NJ, Sterndorff B (1972) Serial determinations of plasma catecholamines in myocardial infarction. Circulation 46:846–855
Gerdes H, Bickenbach R, Hardewig A (1969) Noradrenalin- und Adrenalinausscheidung beim Herzinfarkt. Verh Dtsch Ges Inn Med 75:422–426
Gerdes H, Littmann KP, Egbring R, Hardewig A, Bickenbach R (1971) Die Wirkung von Heparin and Xylocain auf die Adrenalin- und Noradrenalinausscheidung bei Patienten mit Herzinfarkt. Verh Dtsch Ges Inn Med 77:896–900
Nelson PG (1970) Effect of heparin on serum-free fatty acids, plasma catecholamines, and the incidence of arrhythmias following acute myocardial infarction. Br Med J 3:735–737
Griffiths J, Leung F (1971) The sequential estimation of plasma catecholamines and whole blood histamine in myocardial infarction. Am Heart J 82:171–179
Baker C, Bray C, McDonald A, Restieaux N (1969) Plasma-catecholamines after cardiac infarction. Lancet 2:1021–1023
Siggers DC, Salter C, Fluck DC (1971) Serial plasma adrenaline and noradrenaline levels in myocardial infarction using a new double-isotope technique. Br Heart J 33:878–883
Hayashi KD, Moss AJ, Yu PN (1969) Urinary catecholamine excretion in myocardial infarction. Circulation 40:473–481
Jewitt DE, Mercer CJ, Reid D, Valori C, Thomas M, Shillingford JP (1969) Free noradrenaline and adrenaline excretion in relation to the development of cardiac arrhythmias and heart-failure in patients with acute myocardial infarction. Lancet I:635–641
Jequier E, Perret C (1970) Urinary excretion of catecholamines and their main metabolites after myocardial infarction; relationship to the clinical syndrome. Eur J Clin Invest 1:77–83
Klein RF, Troyer WG, Thompson HK, Bogdonoff MD, Wallace AG (1968) Catecholamine excretion in myocardial infarction. Arch Int Med 122:476–482
Strange RC, Rowe MJ, Oliver MF (1978) Lack of relation between venous plasma total catecholamine concentrations and ventricular arrhythmias after acute myocardial infarction. Br Med J 3:921–922
Staszewska-Barczak J (1971) The reflex stimulation of catecholamine secretion during the acute stage of myocardial infarction in the dog. Clin Sci 41:419–439
Yusuf S, Ramsdale D, Peto R, Furse L, Bennet D, Bray C, Sleight P (1980) Early intravenous atenolol treatment in suspected acute myocardial infarction. Lancet 2:273–276
Peuler JD, Johnson GA (1975) A sensitive radioenzymatic assay of plasma catecholamines: Initial studies in suppine normotensive subjects. Clin Res 23:474 [Abstr]
Van der Meer J, Nieweg HO, van der Wall E (1983) Platelet activation and intravscular platelet consumption contributing to acute myocardial infarction. Thromb Haemost 50:97 [Abstr]
Van Hulsteijn H, Bertina RM, Briet E (1983) Beta-thromboglobulin is a more sensitive index of in vivo alpha-granule release than platelet factor 4. Thromb Haemost 50:134 [Abstr]
Owen J, Nichols AB, Gold KD, Marcella JJ (1983) Platelet activation and thrombin action in the coronary circulation during pacing-induced myocardial ischemia. Thromb Haemost 50:96 [Abstr]
Jaffe AS, Lee RG, Perez JE, Geltman EM, Wilner GD, Sobel BE (1984) Lack of elevation of platelet factor IV in plasma from patients with myocardial infarction. J Am Coll Cardiol 4:653–659
Douglas JT, Lowe GDO, Forbes CD, Prentice CRM (1983) Plasma fibrinopeptide A and beta-thromboglobulin in patients with chest pain. Thromb Haemost 50:541–542
Bakhle YS, Vane JR (1974) Pharmacokinetic function of the pulmonary circulation. Physiol Rev 54:1007–1045
Vetter NJ, Strange RC, Adams W, Oliver MF (1974) Initial metabolic and hormonal response to acute myocardial infarction. Lancet 1:284–288
Straton JR, Malpass TW, Ritchie JL, Pfeifer MA, Harker LA (1982) Studies of platelet factor 4 and beta-thromboglobulin release during exercise: Lack of relationship to myocardial ischemia. Circulation 66:33–43
Moschos CB, Haider B, Khan Y, Lyons MM, Regan TJ (1978) Relation of platelets to catecholamine-induced myocardial injury. Cardiovasc Res 12:243–246
Weksler BB, Gillick M, Pink J (1977) Effect of propanolol on platelet function. Blood 49:185–196
Gjesdal K (1976) Platelet function and plasma-free fatty acids during acute myocardial infarction and severe angina pectoris. Scand J Haematol 17:205–212
Handin RI, McDonough M, Lesch M (1978) Elevation of platelet factor four in acute myocardial infarction: Measurement by radioimmunoassay. J Lab Clin Med 91:340–349