Polymethylene Derivatives of Nucleic Bases with ω-Functional Groups: II. Adenine and Hypoxanthine Derivatives

Russian Journal of Bioorganic Chemistry - Tập 27 - Trang 167-172 - 2001
A. A. Makinsky1, A. M. Kritzyn1, E. A. Ul'yanova2, O. D. Zakharova2, D. V. Bugreev2, G. A. Nevinsky2
1Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia
2Novosibirsk Institute of Bioorganic Chemistry, Siberian Division, Russian Academy of Sciences, Novosibirsk, Russia

Tóm tắt

N 9-Polymethylene derivatives of adenine and hypoxanthine with various functional groups in the ω-position of the alkyl substituent were synthesized. Their physicochemical properties and effect on the HIV reverse transcriptase and DNA topoisomerase I were studied.

Tài liệu tham khảo

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