Kinase Polo-like 1 (Plk1): Một Nhân Tố Đáng Ngạc Nhiên Trong Sao Chép DNA

Springer Science and Business Media LLC - Tập 7 - Trang 1-7 - 2012
Bing Song1,2, X Shawn Liu3,2, Xiaoqi Liu3,2
1Department of Biological Sciences, Purdue University, West Lafayette, USA
2Purdue Center for Cancer Research, Purdue University, West Lafayette, USA
3Department of Biochemistry, Purdue University, West Lafayette, USA

Tóm tắt

Việc điều chỉnh quá trình tiến triển của chu kỳ tế bào là rất quan trọng cho việc duy trì tính toàn vẹn của bộ gen, và các kinase tương tự Polo (Plks) đã được xác định là những điều tiết chính của quá trình này. Đã được chứng minh rằng kinase Polo-like 1 (Plk1) đóng vai trò quan trọng trong quá trình phân bào, nhưng ít được biết đến về chức năng của nó ở các giai đoạn khác của chu kỳ tế bào. Trong bài viết này, chúng tôi tóm tắt các chức năng của Plk1 trong quá trình sao chép DNA, tập trung vào những sự kiện phân tử liên quan đến Phức hợp Nhận diện Nguyên thủy (ORC), phức hợp thiết yếu cho việc khởi động sao chép DNA. Trong bối cảnh phosphoryl hóa Orc2 của Plk1, chúng tôi cũng nhấn mạnh việc điều chỉnh Orc2 ở các sinh vật khác nhau. Bài đánh giá này nhằm cung cấp một cái nhìn về cách Plk1 điều phối quá trình sao chép DNA trong pha S với sự phân chia nhiễm sắc thể trong quá trình phân bào, và điều phối toàn bộ chu kỳ tế bào.

Từ khóa

#Polo-like kinase #Plk1 #chu kỳ tế bào #sao chép DNA #Phức hợp Nhận diện Nguyên thủy #phosphoryl hóa #Orc2

Tài liệu tham khảo

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