Polar Constituents of Marrubium thessalum Boiss. & Heldr. (Lamiaceae) and their Cytotoxic/Cytostatic Activity

Phytotherapy Research - Tập 26 Số 12 - Trang 1800-1806 - 2012
Aikaterini Argyropoulou1, Pinelopi Samara2, Ourania E. Tsitsilonis2, Helen Skaltsa3,1
1Department of Pharmacognosy and Chemistry of Natural Products, Faculty of Pharmacy, University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece
2Department of Animal and Human Physiology, Faculty of Biology, University of Athens, Panepistimiopolis Zografou, 15784 Athens, Greece
3Assoc. Prof. Dr Helen Skaltsa, Department of Pharmacognosy and Chemistry of Natural Products, Faculty of Pharmacy, University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece.

Tóm tắt

The methanol extract of the aerial parts of Marrubium thessalum Boiss. & Heldr. (Lamiaceae) afforded 30 phenolic metabolites, belonging to the classes of phenylethanoid glycosides, flavonoids and simple phenolic compounds. The crude methanol extract as well as the secondary metabolites were screened for their cytotoxic/cytostatic effects against four human cancer cell lines, specifically HeLa, MCF‐7, FM3 and HCT‐116 and demonstrated considerable cell growth‐inhibitory activity. The differential cytotoxicity of the compounds implied possible structure‐activity relationships. Selected compounds were evaluated for their toxicity against human peripheral blood mononuclear cells, where some of them showed marginal toxic effects. The results suggest that M. thessalum produces secondary metabolites that demonstrate selective anticancer activity concomitantly with reduced toxicity on lymphocytes. The structure of such compounds can eventually lead to the development of novel pharmaceutical agents. Copyright © 2012 John Wiley & Sons, Ltd.

Từ khóa


Tài liệu tham khảo

10.1016/j.phytochem.2009.03.011

10.1002/cbdv.201000215

10.1055/s-2003-41113

10.1016/j.bmcl.2011.03.021

10.1007/s11745-005-1449-2

10.2174/092986708785908996

10.1111/j.1582-4934.2009.00695.x

10.1055/s-0030-1250162

10.1016/j.bse.2007.02.006

Karioti A, 2005, Secondary metabolites from Marrubium velutinum, growing wild in Greece, Z Naturforsch B, 60, 328, 10.1515/znb-2005-0316

10.1016/j.bmc.2007.01.035

10.1016/S0031-9422(03)00242-5

10.1021/np068054v

10.1016/S0305-1978(99)00058-7

Piozzi F, 2006, The diterpenoids of the genus Marrubium (Lamiaceae), Nat Prod Commun, 1, 585

10.1002/med.10033

10.1016/j.bse.2005.10.006

10.1016/S0378-8741(01)00415-9

10.1080/10575630290013576

10.1248/bpb.18.1396

10.1016/0031-9422(92)83452-5

10.1016/0031-9422(88)87034-1

Thông tin
Thông tin xuất bản

Phytotherapy Research

Tập 26 Số 12

1800-1806

Thông tin tác giả