Manuel Pombo1, J Barreiro1, A Peñalva2, Federico Mallo3, Felipe F. Casanueva2, Carlos Diéguez3
1Department of Paediatrics Hospital General de Galicia Clinico Universitario, University of Santiago de Compostela, Spain
2Department of Medicine Hospital General de Galicia Clinico Universitario, University of Santiago de Compostela, Spain
3Department of Physiology Hospital General de Galicia Clinico Universitario, University of Santiago de Compostela, Spain
Tóm tắt
Eighteen children with short stature were evaluated for growth hormone (GH) reserve after pharmacological tests and a single iv injection of GH‐RP‐6. These children were divided into two groups: 10 were diagnosed as having idiopathic GH deficiency by classical stimulation tests (group A) and the remaining 8 (group B) were considered growth‐retarded children with normal GH secretion, following conventional stimulation, but reduced endogenous GH secretion. The results were compared with a group of 12 normal children. As a group, patients in group A showed a lower GH response to GH‐RP‐6, while patients in group B had a similar response as normal controls. However, on an individual basis, a considerable degree of overlapping in responses among the three groups was evident. These data indicate that, on an individual basis, GH‐RP‐6 testing is not of diagnostic value in children suspected of having idiopathic GH deficiency.GH deficiency, GH‐RP‐6, short stature C Dieguez, PO Box 563, 15705 Santiago de Compostela, Spain
