Mario Mancini1, Angela A. Rivellese1, Paolo Rubba1, Gabriele Riccardi
1Center for Arteriosclerosis and Metabolic Diseases, Semeiotica Medica, 2nd Faculty of Medicine, Naples
Tóm tắt
Plasma lipoprotein abnormalities in maturity onset diabetes (MOD) reflect both enhanced production and impaired removal of triglyceride-rich lipoproteins. Hyper-glycemia and hyperinsulinemia lead to overproduction of very-low-density lipoproteins by the liver. Fat tolerance is reduced in MOD patients: this might be due to low lipoprotein lipase activity (LLA) and/or to low incorporation of LLA-released fatty acids into adipose tissue glyceride. The finding of abnormal low-density lipoprotein composition, with relative enrichment in triglyceride, suggests remnant particle accumulation.
