Phytochemical Analysis of Extractive Substances Extracted by Different Methods from the Underground Part of Aconitum Septentrionale L., and the Development of Cream-Gels Based on Them
Tóm tắt
The work is devoted to the study of the phytochemical composition of subcritical extracts of the underground part of aconite high (Aconitum septentrionale L.). The samples of roots and rhizomes of Aconitum septentrionale grown in the Altai Republic were studied. The quality characteristics of plant biomass were determined: moisture content, ash content, quantitative content of biologically active substances extracted by methods of sequential extraction and sequential processing of plant materials under subcritical conditions. The group composition of biologically active substances of Aconitum septentrionale has been established. The quantitative content of biologically active substances of alkaloid nature isolated from the roots and rhizomes of Aconitum septentrionale by different methods was determined. It is shown that the content of alkaloids extracted under subcritical conditions for 2 h is higher than those extracted by maceration for 16 h. A formulation has been developed to create a cream gel based on extracts of Aconitum septentrionale extracted in various ways. The physico-chemical parameters were analyzed and the effectiveness of cream-gels developed using extracts obtained by various methods from the roots and rhizomes of high aconite was revealed. The data presented in the article are of interest for the creation of biologics based on extracts of Aconitum septentrionale, promising for use in the pharmaceutical industry.
Tài liệu tham khảo
Kremsa, A.A. and Pushkareva, M.S., Molodoy Uch., 2016, no. 12(116), pp. 504–511.
Plemenkov, V.V., New Advances in Chemistry and Chemical Technology of Plant Raw Materials. Materials of the V All-Russian Scientific Conference, Barnaul, 2009, vol. 2, pp. 11–14.
Pogodayeva, N.N., Zhapova, TS., and Vereshchagin, A.L., Physiological and Biochemical Aspects of the Study of Medicinal Plants: Abstracts of the Intern. Meeting Dedicated to the Memory of V.G. Minaeva, Novosibirsk, 1998, pp. 148–149.
Wild medicinal plants of the USSR, Moscow, 1976, 288 p.
Alefirov, A.N., Aconite Against Cancer and Other Diseases, St. Petersburg, 2004, pp. 54–87.
Povet’yeva, T.N. and Lysenkova, M.G., The Contribution of Young Biologists to the Solution of Issues of the Food Program and Environmental Protection: Abstracts of the 11th Conference, Ulan-Ude, 1987, pp. 116–117.
Patent 2189832 (RU). 2002.
Mirovich, V.M., Goryachkina, Ye.G., Fedoseyeva, G.M., and Bocharova, G.I., Determination of the Authenticity of Whole Medicinal Plant Materials: a Study Guide, Irkutsk, 2013.
Leonova, M.V. and Klimochkin, Yu.N., Extraction Methods for the Manufacture of Medicines from Plant Materials: a Teaching Aid, Samara, 2012, 118 p.
Muzychkina, R.A., Technology of Production and Analysis of Phytopreparations, Almaty, 2011, 360 p.
Maksimenko, E.V., Khizrieva, S.S., Borisenko, S.N., Lekar, A.V., Borisenko, N.I., and Minkin, V.I., Russ. J. Physical Chem. B, 2021, vol. 15, no. 7, pp. 1196–1199.
Khizriyeva, S.S., Borisenko, S.N., Maksimenko, Ye.V., Zharkova, G.V., and Borisenko, N.I., Khim. Rastit. Syr’ya, 2022, no. 2, pp. 137–146. https://doi.org/10.14258/jcprm.20220210519
Sinov, M.Yu. and Shapovalova, O.V., Sverkhkritich. Flyuidy: Teor. Prakt., 2020, vol. 15, no. 3, pp. 87–102. https://doi.org/10.34984/SCFTP.2020.15.3.010
Patent 2414922 (RU). 2011.
Muzychkina, R.A., Reactions and Reagents for the Chemical Analysis of some Groups of Biologically Active Substances in Medicinal Plant Materials. Tutorial, Almaty, 2002, 283 p.
Korul’kin, D.Yu. and Muzychkina, R.A., Laboratory Workshop on Chemistry and Technology of Natural Compounds, Almaty, 2016, 90 p.
Farkhutdinov, R.G., Fundamentals of Phytochemical Analysis: Textbook, Ufa, 2016, 137 p.
Aroyan, M.V., Development of the Composition and Technology of Medicinal Products of Sweet Clover and Milky-White Iris Grass: Author, Dis. Cand. Farm. Sci., St. Petersburg, 2021, 24 p.
Obolenskaya A.V., Laboratory Work on the Chemistry of Wood and Cellulose, Moscow, 1991, 320 p.
Guidelines for the Experimental Study of New Pharmacological Substances, Ed., Fisenko, V.P., Moscow, 2000, 398 p.