Physiological Role of Silent Receptors of Atrial Natriuretic Factor

American Association for the Advancement of Science (AAAS) - Tập 238 Số 4827 - Trang 675-678 - 1987
Thomas Maack1, Muneya Suzuki1, Fernando Antônio de Almeida1, Daniel R. Nussenzveig1, Robert M. Scarborough2, Glenn McEnroe2, John Lewicki2
1Department of Physiology, Cornell University Medical College, New York, NY 10021.
2California Biotechnology, Inc., Mountain View, CA 94043.

Tóm tắt

A ring-deleted analog of atrial natriuretic factor—des[Gln 18 , Ser 19 , Gly 20 , Leu 21 , Gly 22 ] ANF 4-23 -NH 2 (C-ANF 4-23 )—binds with high affinity to approximately 99% of ANF receptors in the isolated perfused rat kidney. In this preparation, C-ANF 4-23 is devoid of detectable renal effects and does not antagonize any of the known renal hemodynamic and natriuretic actions of biologically active ANF 1-28 . In contrast, both C-ANF 4-23 and ANF 1-28 increase sodium excretion and decrease blood pressure in intact anesthetized rats. This apparent contradiction is resolved by the finding that the ring-deleted analog markedly increases plasma levels of endogenous immunoreactive ANF in the rat. The results show that the majority of the renal receptors of ANF are biologically silent. This new class of receptors may serve as specific peripheral storage-clearance binding sites, acting as a hormonal buffer system to modulate plasma levels of ANF.

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Tài liệu tham khảo

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American Association for the Advancement of Science (AAAS)

Tập 238 Số 4827

675-678

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