Phyllodes tumours of the breast: a clinicopathological review of thirty‐two cases

Histopathology - Tập 27 Số 3 - Trang 205-218 - 1995
Christopher Moffat1, Sarah E. Pinder1, AR Dixon2, C.W. Elston1, R.W. Blamey2, Ian O. Ellis1
1Departments of Histopathology, City Hospital, Nottingham
2Departments of Surgery, City Hospital, Nottingham

Tóm tắt

We have reviewed the histological features and clinical outcome in 32 women with phyllodes tumours of the breast diagnosed in Nottingham between 1975 and 1990. We assessed 23 tumours as histologically benign, four as borderline and five as malignant. After clinical follow up for periods ranging from 36 months to 221 months (median 135 months), six of 23 benign tumours have recurred locally; in all these cases the original tumours had been incompletely excised. There were no recurrences amongst 10 benign tumours in which excision had been complete. Benign tumours which recurred showed a tendency to greater stromal cellularity and more pronounced stromal overgrowth than incompletely excised lesions which did not recur, but these differences were not statistically significant. The recurrent tumours resembled the respective original lesions histologically, except in one case in which two local recurrences were histologically malignant. The recurrent tumours were controlled by further excision or mastectomy in all cases and none have metastasized. All four borderline tumours were completely excised at initial surgery and none have recurred or metastasized. One of the five malignant tumours recurred within two months of incomplete excision, with widespread infiltration of the chest wall, although the patient died of unrelated causes. The other four malignant tumours have not recurred. We conclude that presence of tumour at the margins of the excised specimen is the major determinant of local recurrence in phyllodes tumours and that the histological features are of secondary importance. These findings are discussed in relation to other published series in the literature.

Từ khóa


Tài liệu tham khảo

Azzopardi JG., 1979, Problems in Breast Pathology, 346

Page DL, 1987, Diagnostic Histopathology of the Breast, 341

Haagensen CD., 1986, Diseases of the Breast, 284

10.1002/1097-0142(195111)4:6<1286::AID-CNCR2820040614>3.0.CO;2-T

10.1002/1097-0142(197805)41:5<1974::AID-CNCR2820410543>3.0.CO;2-C

10.1002/bjs.1800530517

10.1002/1097-0142(195403)7:2<335::AID-CNCR2820070219>3.0.CO;2-J

10.1002/1097-0142(196506)18:6<697::AID-CNCR2820180607>3.0.CO;2-L

McDivitt RW, 1967, Cystosarcoma Phyllodes, Johns Hopkins Med. J., 120, 33

10.1002/1097-0142(197609)38:3<1402::AID-CNCR2820380346>3.0.CO;2-9

10.1093/ajcp/70.2.211

Grigioni WF, 1982, A Clinicopathological Study of Cystosarcoma Phyllodes. Twenty Case Reports, Arch. Anat. Cytol. Path., 30, 303

10.1016/0002-9610(87)90601-5

10.1002/1097-0142(19891001)64:7<1486::AID-CNCR2820640721>3.0.CO;2-7

Grimes MM., 1992, Cystosarcoma Phyllodes of the Breast: Histologic Features. Flow Cytometric Analysis, and Clinical Correlations, Modern Pathology, 5, 232

10.1002/1097-0142(19890615)63:12<2532::AID-CNCR2820631229>3.0.CO;2-Q

Ciatto S, 1992, Phyllodes Tumor of the Breast: A Multicentre Series of 59 Cases, Eur. J. Surg. Oncol., 18, 545

10.1016/S0959-8049(05)80119-4

Halverson JD, 1974, Cystosarcoma Phyllodes of the Breast, The American Surgeon, 40, 295

10.1002/jso.2930450111

10.1111/j.1445-2197.1992.tb07534.x

10.1016/S0002-9610(05)80849-9

10.1002/1097-0142(19930515)71:10<3020::AID-CNCR2820711022>3.0.CO;2-G

10.1002/1097-0142(196712)20:12<2090::AID-CNCR2820201206>3.0.CO;2-L

10.1002/1097-0142(19921015)70:8<2115::AID-CNCR2820700818>3.0.CO;2-K

10.1002/1097-0142(19861115)58:10<2282::AID-CNCR2820581021>3.0.CO;2-2

Koerner FC, 1994, Fibroadenoma: Morphological Observations and a Theory of Pathogenesis, Pathol. Annu., 29, 1

Rix DB, 1971, Cystosarcoma Phyllodes (Cellular Intracanalicular Fibroadenoma): Clinical‐Pathological Relationships, Canadian J. Surg., 14, 31

10.1002/1097-0142(19911101)68:9<2017::AID-CNCR2820680929>3.0.CO;2-V

10.1002/1097-0142(19920101)69:1<141::AID-CNCR2820690125>3.0.CO;2-1

10.1002/1097-0142(196807)22:1<22::AID-CNCR2820220105>3.0.CO;2-R

10.1016/0002-9610(94)90238-0

Smola MG, 1993, The Impact of Resection Margins in the Treatment of Primary Sarcomas of the Breast. A Clinicopathological Study of 8 Cases with review of the Literature, Eur. J. Surg. Oncol., 19, 61

10.1111/j.1365-2559.1991.tb00229.x

10.1016/0002-9610(82)90016-2

10.1002/dc.2840050107

10.1016/0046-8177(92)90268-8

10.1002/jso.2930040208

Thông tin
Thông tin xuất bản

Histopathology

Tập 27 Số 3

205-218

Thông tin tác giả