α-Synuclein phosphoryl hóa trong bệnh Parkinson

Yu Wang1,2, Min Shi2, Kathryn A. Chung3, Cyrus P. Zabetian4,5, James B. Leverenz4,6,7, Daniela Berg8,9, Karin Srulijes8,9, John Q. Trojanowski10, Virginia M.‐Y. Lee10, Andrew Siderowf11, Howard I. Hurtig11, Irene Litvan12, Mya C. Schiess13, Elaine R. Peskind6,7, M. Masuda14, Masato Hasegawa14, Xiangmin Lin2, Catherine Pan2, Douglas Galasko15, David S. Goldstein16, Poul Henning Jensen17, Hui Yang2, Kevin C. Cain18, Jing Zhang2
1Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
2Department of Pathology, University of Washington School of Medicine, Seattle, WA 98104, USA
3Department of Neurology, Oregon Health and Science University, Portland, OR 97239, USA
4Department of Neurology, University of Washington School of Medicine, Seattle, WA 98104, USA.
5Geriatric Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
6Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98105, USA
7Mental Illness Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA.
8Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University of Tuebingen, 72076 Tuebingen, Germany.
9German Center for Neurodegenerative Diseases, University of Tuebingen, 72076 Tuebingen, Germany.
10Institute on Aging, Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
11Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19107, USA.
12Division of Movement Disorders, University of Louisville School of Medicine, Louisville, KY 40202, USA.
13Department of Neurology, University of Texas Health Science Center, Houston, TX 77030, USA
14Department of Neuropathology and Cell Biology, Tokyo Metropolitan Institute of Medical Science, Setagaya-ku, Tokyo 156-8585, Japan.
15Department of Neurosciences, University of California at San Diego, La Jolla, CA 92093, USA
16Clinical Neurocardiology Section, Community Networks Program, Division of Intramural Research, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
17Department of Medical Chemistry, Aarhus University, 8000 Aarhus C, Denmark.
18Department of Biostatistics, University of Washington, Seattle, WA 98105, USA

Tóm tắt

Thử nghiệm phát hiện α-synuclein phosphoryl hóa trong dịch não tủy (CSF) có thể giúp chẩn đoán bệnh Parkinson và xác định mức độ nghiêm trọng của bệnh.

Từ khóa


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