Phenotype and function of human T lymphocyte subsets: Consensus and issues
Tóm tắt
In recent years, a tremendous effort has been devoted to the detailed characterization of the phenotype and function of distinct T cell subpopulations in humans, as well as to their pathway(s) of differentiation and role in immune responses. But these studies seem to have generated more questions than definitive answers. To clarify issues related to the function and differentiation of T cell subsets, one session of the MASIR 2008 conference was dedicated to this topic. Several points of consensus and discord were highlighted in the work presented during this session. We provide here an account of these points, including the relative heterogeneity of T cell subpopulations during infections with distinct pathogens, the relationship between phenotypic and functional T cell attributes, and the pathway(s) of T cell differentiation. Finally, we discuss the problems which still limit general agreement. Published 2008 Wiley‐Liss, Inc.
Từ khóa
Tài liệu tham khảo
Hesperger AR, 2008, Flow cytometric detection of perforin upregulation in human CD8 T cells, Cytometry Part A, 73A
van Baalen C, 2008, FATT‐CTL assay for detection of antigen‐specific cell‐mediated cytotoxicity, Cytometry Part A, 73A
Chattopadhyay P, 2008, Techniques to improve the direct ex vivo detection of low frequency antigen‐specific CD8+ T cells with peptide‐major histocompatibility complex class I tetramers, Cytometry Part A, 73A
Fuhrmann S, 2008, How flow cytometry is changing the study of TB immunology and clinical diagnosis, Cytometry Part A, 73A
Cecconi V, 2008, Use of MHC Class II tetramers to investigate CD4+ T cell responses: Problems and solutions, Cytometry Part A, 73A
Meier S, 2008, The influence of different stimulation conditions on the assessment of antigen‐induced CD154 expression on CD4+ T cells, Cytometry Part A, 73A