Phase 3 study of recombinant factor VIII Fc fusion protein in severe hemophilia A

Blood - Tập 123 Số 3 - Trang 317-325 - 2014
Johnny Mahlangu1, Jerry S. Powell2, Margaret V. Ragni3, Pratima Chowdary4, Neil C. Josephson5, Ingrid Pabinger6, Hideji Hanabusa7, Naresh Gupta8, Roshni Kulkarni9, Patrick Fogarty10, David J. Perry11, Amy D. Shapiro12, John Pasi13, Shashikant Apte14, Ivan Nestorov15, Haiyan Jiang15, Shuanglian Li15, Srividya Neelakantan15, Lynda M. Cristiano15, Jaya Goyal15, Jürg M. Sommer15, Jennifer Dumont15, Nigel Dodd15, Karen Nugent15, Gloria Vigliani15, Aoife M. Brennan15, Glenn F. Pierce15
1Haemophilia Comprehensive Care Centre, Faculty of Health Sciences, University of the Witwatersrand and National Health Laboratory Service., Johannesburg, South Africa
2University of California at Davis, Davis, California;
3University of Pittsburgh and the Hemophilia Center of Western Pennsylvania, Pittsburgh, PA;
4Katharine Dormandy Haemophilia Centre and Thrombosis Unit, Royal Free Hospital, London, United Kingdom;
5Puget Sound Blood Center, Seattle, WA
6Universitätsklinik für Innere Medizin I, Medizinische Universität Wien, Wien, Austria
7Department of Hematology, Ogikubo Hospital, Suginami-ku, Tokyo, Japan;
8Haemophilia Centre and Department of Medicine, Maulana Azad Medical College & Associated Lok Nayak Jai Prakash Narayan Hospital, New Delhi, India;
9Department of Pediatrics and Human Development, Michigan State University, East Lansing, MI;
10Penn Comprehensive Hemostasis and Thrombosis Program, Hospital of the University of Pennsylvania, Philadelphia, PA;
11Cambridge Haemophilia & Thrombosis Centre, Addenbrooke’s Hospital, Cambridge, United Kingdom;
12Indiana Hemophilia and Thrombosis Center, Department of Hematology, Indianapolis, IN;
13Royal London Haemophilia Centre, Barts and the London School of Medicine and Dentistry, London, United Kingdom
14Sahyadri Hospital, Department of Hematology, Mahara, India; and
15Biogen Idec Hemophilia, Cambridge, MA

Tóm tắt

Key Points

A novel recombinant factor VIII with prolonged half-life, rFVIIIFc, was developed to reduce prophylactic injection frequency. rFVIIIFc was well-tolerated in patients with severe hemophilia A, and resulted in low bleeding rates when dosed 1 to 2 times per week.

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Tài liệu tham khảo

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