Tính chất Dược lý của Chalcone: Tổng quan Nghiên cứu Tiền lâm sàng và Bằng chứng Lâm sàng
Tóm tắt
Chalcones là một trong những flavonoid sinh học hàng đầu với tiềm năng điều trị được đồn thổi đến hàng loạt hoạt động sinh học đã được một loạt nghiên cứu tiền lâm sàng và lâm sàng điều tra. Trong bài báo này, các cơ sở dữ liệu khoa học khác nhau đã được tìm kiếm để lấy lại các nghiên cứu mô tả hoạt động sinh học của chalcone và các dẫn xuất của chúng. Bài đánh giá này mô tả một cách toàn diện các nghiên cứu tiền lâm sàng về chalcone và các dẫn xuất của chúng, mô tả ý nghĩa to lớn của chúng như các tác nhân chống tiểu đường, chống ung thư, chống viêm, kháng khuẩn, chống ôxy hóa, chống ký sinh trùng, tác động tâm thần và bảo vệ thần kinh. Bên cạnh đó, các thử nghiệm lâm sàng đã tiết lộ việc sử dụng của chúng trong điều trị suy tĩnh mạch mãn tính, các tình trạng da và ung thư. Các nghiên cứu về sinh khả dụng trên chalcone và dẫn xuất cho thấy khả năng cản trở và cải thiện trong liên hệ với ứng dụng chức năng dinh dưỡng và dược phẩm. Các cơ chế phức tạp và đa dạng cơ bản của các hành động của chalcone cho thấy khả năng của chúng trong việc điều chỉnh một số dòng tế bào ung thư, ức chế một số vi sinh vật và ký sinh trùng bệnh lý, và kiểm soát một số phân tử tín hiệu và chuỗi liên quan đến thay đổi bệnh. Các nghiên cứu lâm sàng về chalcone đã tiết lộ sự vắng mặt chung của các tác dụng phụ bên cạnh việc giảm các triệu chứng lâm sàng với sinh khả dụng khá tốt. Các nghiên cứu thêm là cần thiết để làm sáng tỏ cấu trúc hoạt động, mối lo ngại về độc tính, cơ sở tế bào của cách thức hoạt động, và sự tương tác với các phân tử khác.
Từ khóa
#chalcone #tiền lâm sàng #lâm sàng #sinh khả dụng #dược lýTài liệu tham khảo
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