Pharmacological Inhibition of a MicroRNA Family in Nonhuman Primates by a Seed-Targeting 8-Mer AntimiR

American Association for the Advancement of Science (AAAS) - Tập 5 Số 212 - 2013
Veerle Rottiers1,2, Susanna Obad3, Andreas Petri4, Robert W. McGarrah5,6,7, Marie Lindholm3, Joshua C. Black8,2, Sumita Sinha5,6, Robin J Goody9, Matthew S. Lawrence9, Andrew S. deLemos10, Henrik F. Hansen3, Steve Whittaker9, Steve Henry9, Rohn Brookes9, S. Hani Najafi‐Shoushtari1,11,2, Raymond T. Chung10, Johnathan R. Whetstine8,2, Robert E. Gerszten5,6, Sakari Kauppinen4, Anders M. Näär1,2
1Department of Cell Biology, Harvard Medical School, Boston, MA 02115 USA
2Massachusetts General Hospital Cancer Center, Charlestown, MA 02129 USA
3Santaris Pharma, DK-2970 Hørsholm, Denmark.
4Department of Haematology, Aalborg University Hospital, DK-2450 Copenhagen SV, Denmark.
5Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
6Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA 02114, USA
7Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
8Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
9RxGen Inc., 100 Deepwood Drive, Hamden, CT 06517, USA.
10Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
11Department of Cell and Developmental Biology, Weill Cornell Medical College in Qatar, Education City, Qatar Foundation, P. O. Box 24144, Doha, Qatar.

Tóm tắt

Long-term treatment of obese, insulin-resistant nonhuman primates with a seed-targeting antimiR oligonucleotide against the microRNA-33 family derepresses hepatic expression of miR-33 targets, increases circulating HDL cholesterol, and has a clean safety profile.

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American Association for the Advancement of Science (AAAS)

Tập 5 Số 212

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