Pharmacokinetics of Amitriptyline and One of Its Metabolites, Nortriptyline, in Rats: Little Contribution of Considerable Hepatic First-Pass Effect to Low Bioavailability of Amitriptyline Due to Great Intestinal First-Pass Effect

Journal of Pharmaceutical Sciences - Tập 98 - Trang 1587-1601 - 2009
Soo K. Bae1, Kyung H. Yang1, Dipendra K. Aryal2, Yoon G. Kim2, Myung G. Lee1
1College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, San 56-1, Shinlim-Dong, Kwanak-Gu, Seoul 151-742, South Korea
2Department of Pharmacology, College of Medicine, Dankook University, San 29, Anseo-Dong, Cheonan-Si, Chunam, South Korea

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