Pharmacokinetics and analgesic effect of ropivacaine following ilioinguinal/iliohypogastric nerve block in children

Paediatric Anaesthesia - Tập 11 Số 4 - Trang 415-420 - 2001
B Dalens1, Claude Ecoffey2, Agnès Joly2, E. Giaufré3, U. Gustafsson4, Gunilla Huledal4, Lars E. Larsson4
1Department of Anaesthesia and Intensive Care, Hotel Dieu Hospital, Clermont Ferrand, France
2Department of Anaesthesia and Intensive Care, Pontchaillou Hospital, Rennes, France
3Department of Anaesthesia and Intensive Care, Saint Joseph Hospital, Marseilles, France
4Clinical R & D, AstraZeneca R & D, Södertälje, Sweden

Tóm tắt

Background: The aim was to investigate the efficacy, tolerance and pharmacokinetics of ropivavcaine when administered for ilioinguinal/iliohypogastric block in children. Methods: We examined the pharmacokinetics and analgesic efficacy after ilioinguinal/iliohypogastric nerve block with 3 mg·kg−1 ropivacaine 5 mg·ml−1 in 22 children, aged 1–12 years, who were scheduled for inguinal surgery. Sixteen of 22 patients had a postoperative pain score < 4 (Objective Pain Scale). Nine children were given supplementary analgesics during the first six postoperative hours. Results: The peak plasma concentration of total ropivacaine was 1.50 ± 0.93 mg·l−1 (mean ± SD) (range 0.64–4.77 mg·l−1) 15–64 min after the injection. The peak plasma concentration of free ropivacaine was 0.05 ± 0.03 mg·l−1 (0.02–0.14 mg·l−1), which is well below the threshold for toxicity in adults. The terminal half‐life was 2.0 ± 0.7 h. No safety concerns or symptoms suggestive of systemic toxicity were observed. Conclusions: A dose of 3 mg·kg−1 of ropivacaine given as a single ilioinguinal/iliohypogastric nerve block in 1–12‐year‐old children provides satisfactory postoperative pain relief, and is well tolerated.

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Thông tin xuất bản

Paediatric Anaesthesia

Tập 11 Số 4

415-420

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