Tương Tác Dược Dược Lý Giữa Thuốc Thảo Dược và Thuốc: Cơ Chế và Ý Nghĩa Lâm Sàng

Life - Tập 10 Số 7 - Trang 106
Laura Rombolà1, Damiana Scuteri1, Marilisa Straface1, Chizuko Watanabe2, Luigi Antonio Morrone1, Giacinto Bagetta1, Maria Tiziana Corasaniti3
1Preclinical and Translational Pharmacology, Department of Pharmacy, Health and Nutritional Sciences, Section of Preclinical and Translational Pharmacology, University of Calabria, 87036 Rende, Italy.
2Department of Physiology and Anatomy, Tohoku Pharmaceutical University, 981-8558 Sendai, Japan
3School of Hospital Pharmacy, University “Magna Graecia” of Catanzaro and Department of Health Sciences, University “Magna Graecia” of Catanzaro, 88100 Catanzaro, Italy

Tóm tắt

Hiệu quả điều trị của một loại thuốc hoặc các tác dụng không mong muốn không dự đoán được của nó có thể phụ thuộc vào việc sử dụng đồng thời một loại cây thuốc. Cụ thể, các thành phần trong chiết xuất cây thuốc có thể ảnh hưởng đến khả năng sinh khả dụng, chuyển hóa và thời gian bán hủy của thuốc, dẫn đến độc tính của thuốc hoặc không đạt được phản ứng điều trị. Bài tổng quan này tập trung vào các nghiên cứu lâm sàng nhằm nâng cao nhận thức về khả năng của những thuốc thảo dược được chọn lựa để ảnh hưởng đến dược động học của các thuốc cùng được sử dụng. Hơn nữa, các nghiên cứu in vitro có thể hữu ích để dự đoán các tương tác giữa thuốc thảo dược và thuốc. Cụ thể, chúng giúp làm sáng tỏ các mục tiêu tế bào (protein chuyển hóa hoặc protein vận chuyển) và cơ chế (kích thích hoặc ức chế) mà một thành phần đơn lẻ của thuốc thảo dược tác động. Các tác giả làm nổi bật những khó khăn trong việc dự đoán các tương tác thuốc thảo dược từ dữ liệu in vitro, trong trường hợp nồng độ cao của các chiết xuất hoặc các thành phần của chúng được sử dụng và dược động học không được xem xét. Ngoài ra, cũng thảo luận về khó khăn trong việc so sánh kết quả từ các nghiên cứu trên người khi có các loại chiết xuất thảo dược khác nhau được sử dụng. Các thuốc thảo dược được thảo luận là trong số những sản phẩm bán chạy nhất và được ghi nhận trong phần "Thuốc Thảo Dược Để Sử Dụng Ở Người" của Cơ Quan Dược Phẩm Châu Âu (EMA).

Từ khóa

#Tương tác thuốc thảo dược #dược động học #hiệu quả điều trị #thuốc thảo dược #nghiên cứu lâm sàng #nghiên cứu in vitro.

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