Peripheral immunophenotypes in children with multisystem inflammatory syndrome associated with SARS-CoV-2 infection

Nature Medicine - Tập 26 Số 11 - Trang 1701-1707 - 2020
Michael J. Carter1, Matthew Fish2, A.R. Jennings2, Katie J. Doores3, Paul Wellman4, Jeffrey Seow3, Sam Acors3, Carl Graham3, Emma Timms5, Julia Kenny4, Stuart J. D. Neil3, Michael H. Malim3, Shane M. Tibby4, Manu Shankar‐Hari3
1Department of Women and Children’s Health, King’s College London, London, UK
2Department of Intensive Care Medicine, Guy’s and St Thomas’ NHS Foundation Trust, London, UK
3Department of Infectious Diseases, School of Immunology and Microbial Sciences, King's College London, London, UK
4Paediatric Intensive Care Unit, Evelina London Children’s Hospital, London, UK
5Peter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences, King’s College London, London, UK

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Rowley, A. H. Understanding SARS-CoV-2-related multisystem inflammatory syndrome in children. Nat. Rev. Immunol. 20, 453–454 (2020).

Verdoni, L. et al. An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study. Lancet 395, 1771–1778 (2020).

Riphagen, S., Gomez, X., Gonzalez-Martinez, C., Wilkinson, N. & Theocharis, P. Hyperinflammatory shock in children during COVID-19 pandemic. Lancet 395, 1607–1608 (2020).

Cabrero-Hernandez, M. et al. Severe SARS-CoV-2 infection in children with suspected acute abdomen: a case series from a tertiary hospital in Spain. Pediatr. Infect. Dis. J. 39, e195–e198 (2020).

Belhadjer, Z. et al. Acute heart failure in multisystem inflammatory syndrome in children (MIS-C) in the context of global SARS-CoV-2 pandemic. Circulation 142, 429–436 (2020).

Chiotos, K. et al. Multisystem inflammatory syndrome in children during the coronavirus 2019 pandemic: a case series. J. Pediatr. Infect. Dis. Soc. 9, 393–398 (2020).

Whittaker, E. et al. Clinical characteristics of 58 children with a pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2. JAMA 324, 259–269 (2020).

Ramcharan, T. et al. Paediatric inflammatory multisystem syndrome: temporally associated with SARS-CoV-2 (PIMS-TS): cardiac features, management and short-term outcomes at a UK tertiary paediatric hospital. Pediatr. Cardiol. 2020, 1–11 (2020).

Kaushik, S. et al. Multisystem inflammatory syndrome in children associated with severe acute respiratory syndrome coronavirus 2 infection: a multi-institutional study from New York City. J. Pediatr. https://doi.org/10.1016/j.jpeds.2020.06.045 (2020).

Capone, C. A. et al. Characteristics, cardiac involvement, and outcomes of multisystem inflammatory disease of childhood (MIS-C) associated with SARS-CoV-2 infection. J. Pediatr. https://doi.org/10.1016/j.jpeds.2020.06.044 (2020).

Toubiana, J. et al. Kawasaki-like multisystem inflammatory syndrome in children during the COVID-19 pandemic in Paris, France: prospective observational study. BMJ 369, m2094 (2020).

Feldstein, L. R. et al. Multisystem inflammatory syndrome in U.S. children and adolescents. N. Engl. J. Med. 383, 334–346 (2020).

Dufort, E. M. et al. Multisystem inflammatory syndrome in children in New York State. N. Engl. J. Med. 383, 347–358 (2020).

Sun, B. et al. Kinetics of SARS-CoV-2 specific IgM and IgG responses in COVID-19 patients. Emerg. Microbes Infect. 9, 940–948 (2020).

Long, Q. X. et al. Antibody responses to SARS-CoV-2 in patients with COVID-19. Nat. Med. 26, 845–848 (2020).

Guidance—Paediatric Multisystem Inflammatory Syndrome Temporally Associated with COVID-19 (PIMS) (Royal College of Paediatrics and Child Health, 2020); https://www.rcpch.ac.uk/resources/guidance-paediatric-multisystem-inflammatory-syndrome-temporally-associated-covid-19

Dallaire, F. & Dahdah, N. New equations and a critical appraisal of coronary artery Z scores in healthy children. J. Am. Soc. Echocardiogr. 24, 60–74 (2011).

Newburger, J. W., Takahashi, M. & Burns, J. C. Kawasaki disease. J. Am. Coll. Cardiol. 67, 1738–1749 (2016).

Rowley, A. H. & Shulman, S. T. The epidemiology and pathogenesis of Kawasaki disease. Front Pediatr. 6, 374 (2018).

Fernandez-Cooke, E. et al. Epidemiological and clinical features of Kawasaki disease in Spain over 5 years and risk factors for aneurysm development. (2011–2016): KAWA-RACE study group. PLoS ONE 14, e0215665 (2019).

Tacke, C. E. et al. Five years of Kawasaki disease in the Netherlands: a national surveillance study. Pediatr. Infect. Dis. J. 33, 793–797 (2014).

Long, Q. X. et al. Clinical and immunological assessment of asymptomatic SARS-CoV-2 infections. Nat. Med. 26, 1200–1204 (2020).

Wang, Y. & Jonsson, F. Expression, role, and regulation of neutrophil fcγ receptors. Front. Immunol. 10, 1958 (2019).

Marini, O. et al. Mature CD10+ and immature CD10− neutrophils present in G-CSF-treated donors display opposite effects on T cells. Blood 129, 1343–1356 (2017).

Costa, S., Bevilacqua, D., Cassatella, M. A. & Scapini, P. Recent advances on the crosstalk between neutrophils and B or T lymphocytes. Immunology 156, 23–32 (2019).

Zanoni, I. & Granucci, F. Role of CD14 in host protection against infections and in metabolism regulation. Front. Cell Infect. Microbiol. 3, 32 (2013).

Krutmann, J. et al. Cross-linking Fc receptors on monocytes triggers IL-6 production. Role in anti-CD3-induced T cell activation. J. Immunol. 145, 1337–1342 (1990).

Tanaka, M. et al. Activation of FcγRI on monocytes triggers differentiation into immature dendritic cells that induce autoreactive T cell responses. J. Immunol. 183, 2349–2355 (2009).

Freer, G. & Matteucci, D. Influence of dendritic cells on viral pathogenicity. PLoS Pathog. 5, e1000384 (2009).

Maecker, H. T., McCoy, J. P. & Nussenblatt, R. Standardizing immunophenotyping for the Human Immunology Project. Nat. Rev. Immunol. 12, 191–200 (2012).

Van den Broek, T., Borghans, J. A. M. & van Wijk, F. The full spectrum of human naive T cells. Nat. Rev. Immunol. 18, 363–373 (2018).

Zheng, J., Liu, Y., Lau, Y. L. & Tu, W. γδ-T cells: an unpolished sword in human anti-infection immunity. Cell. Mol. Immunol. 10, 50–57 (2013).

Vignali, D. A., Collison, L. W. & Workman, C. J. How regulatory T cells work. Nat. Rev. Immunol. 8, 523–532 (2008).

Dono, M., Cerruti, G. & Zupo, S. The CD5+ B-cell. Int. J. Biochem. Cell Biol. 36, 2105–2111 (2004).

Mathew, D. et al. Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications. Science https://doi.org/10.1126/science.abc8511 (2020).

Laing, A. G. et al. A consensus COVID-19 immune signature combines immuno-protection with discrete sepsis-like traits associated with poor prognosis. Preprint at medRxiv https://doi.org/10.1101/2020.06.08.20125112 (2020).

Matsuguma, C. et al. Dynamics of immunocyte activation during intravenous immunoglobulin treatment in Kawasaki disease. Scand. J. Rheumatol. 48, 491–496 (2019).

Lamers, M. M. et al. SARS-CoV-2 productively infects human gut enterocytes. Science 369, 50–54 (2020).

Ellinghaus, D. et al. Genomewide association study of severe Covid-19 with respiratory failure. N. Engl. J. Med. https://doi.org/10.1056/NEJMoa2020283 (2020).

Wan, Y. et al. Molecular mechanism for antibody-dependent enhancement of coronavirus entry. J. Virol. 94, e02015-19 (2020).

Liu, L. et al. Anti-spike IgG causes severe acute lung injury by skewing macrophage responses during acute SARS-CoV infection. JCI Insight 4, e123158 (2019).

Davies, P. et al. Intensive care admissions of children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) in the UK: a multicentre observational study. Lancet Child Adolesc. Health https://doi.org/10.1016/S2352-4642(20)30215-7 (2020).

Matics, T. J. & Sanchez-Pinto, L. N. Adaptation and validation of a pediatric sequential organ failure assessment score and evaluation of the Sepsis-3 definitions in critically Ill children. JAMA Pediatr. 171, e172352 (2017).

Cherian, T. et al. Standardized interpretation of paediatric chest radiographs for the diagnosis of pneumonia in epidemiological studies. Bull. World Health Organ. 83, 353–359 (2005).

Pickering, S. et al. Comparative assessment of multiple COVID-19 serological technologies supports continued evaluation of point-of-care lateral flow assays in hospital and community healthcare settings. Preprint at medRxiv https://doi.org/10.1101/2020.06.02.20120345 (2020).

Grehan, K., Ferrara, F. & Temperton, N. An optimised method for the production of MERS-CoV spike expressing viral pseudotypes. MethodsX 2, 379–384 (2015).

Seow, J. et al. Longitudinal evaluation and decline of antibody responses in SARS-CoV-2 infection. Preprint at medRxiv https://doi.org/10.1101/2020.07.09.20148429 (2020).

Wickham, H. et al. Welcome to the Tidyverse. J. Open Source Softw. 4, 1686 (2019).

Kassambara, K. & Mundt, F. factoextra: Extract and visualize the results of multivariate data analyses. R package version 1.0.7 https://cran.r-project.org/web/packages/factoextra/index.html (2020).

Kolde, R. pheatmap: Pretty heatmaps. R package version 1.0.12 https://cran.r-project.org/web/packages/pheatmap/index.html (2019).

RStudio Team RStudio: Integrated Development for R (RStudio, 2020).

R Development Core Team R: A Language and Environment for Statistical Computing (R Foundation for Statistical Computing, 2020); http://www.R-project.org/