Peripheral endothelin A receptor antagonism attenuates carcinoma‐induced pain

European Journal of Pain - Tập 11 - Trang 406-414 - 2007
Brian L. Schmidt1, Victoria Pickering1, Stanley Liu1, Phuong Quang1, John Dolan1, S. Thaddeus Connelly1, Richard C.K. Jordan2,3
1Department of Oral and Maxillofacial Surgery, University of California San Francisco, San Francisco, CA 94143-0440, United States
2Department of Orofacial Sciences, University of California, San Francisco, San Francisco, CA, United States
3Department of Pathology, University of California, San Francisco, San Francisco, CA, United States

Tóm tắt

AbstractIn this study we investigated the role of endothelin‐1 (ET‐1) and its peripheral receptor (ET‐A) in carcinoma‐induced pain in a mouse cancer pain model. Tumors were induced in the hind paw of female mice by local injection of cells derived from a human oral squamous cell carcinoma (SCC). Significant pain, as indicated by reduction in withdrawal thresholds in response to mechanical stimulation, began at four days after SCC inoculation and lasted to 28 days, the last day of measurement. Intra‐tumor expression of both ET‐1 mRNA and ET‐1 protein were significantly upregulated compared to normal tissue, and local administration of the ET‐A receptor selective antagonist, BQ‐123 (100μM) significantly elevated withdrawal thresholds, indicating the induction of an antinociceptive effect. These findings support the suggestion that ET‐1 and ET‐A receptors contribute to the severity of carcinoma‐induced soft tissue cancer pain.

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European Journal of Pain

Tập 11

406-414

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