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Hóa trị nội khí quản trong phẫu thuật cho khối u trên bề mặt phúc mạc
Tóm tắt
Việc điều trị khối u trên bề mặt phúc mạc chủ yếu tập trung vào u mesothelioma phúc mạc ác tính lan tỏa, pseudomyxoma peritonei xuất phát từ ung thư ruột thừa và sự phát tán phúc mạc từ ung thư đường tiêu hóa và ung thư buồng trứng. Sự tiến triển của bệnh làm cho các cục u phúc mạc phân bố khắp khoang bụng chậu. Những nốt này cùng với dịch báng tạo ra sự căng phồng bụng. Khi bệnh tiến triển, những khối u này gây tắc nghẽn ruột dẫn đến các triệu chứng suy nhược và làm giảm chất lượng cuộc sống nghiêm trọng. Trong quá khứ, tiên lượng của bệnh nhân mắc khối u trên bề mặt phúc mạc thường được coi là ảm đạm và việc chữa trị là không khả thi. Gần đây, phẫu thuật cắt bỏ tế bào kết hợp với hóa trị nội khí quản trong quá trình phẫu thuật đã cho thấy sự cải thiện về tỷ lệ sống sót ở những bệnh nhân được chọn lọc mắc bệnh này. Đến nay, nhiều phác đồ hóa trị nội khí quản khác nhau đã được áp dụng. Bài tổng quan này tập trung vào hóa trị nội khí quản trong quá trình phẫu thuật hiện đang được sử dụng cùng với phẫu thuật cắt bỏ tế bào cho việc điều trị khối u trên bề mặt phúc mạc tại Viện Ung thư Washington.
Từ khóa
#hóa trị nội khí quản; khối u phúc mạc; phẫu thuật cắt bỏ tế bào; tiên lượng bệnh nhân; ung thưTài liệu tham khảo
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