Perineurioma: A Distinctive and Underrecognized Peripheral Nerve Sheath Neoplasm

Archives of Pathology and Laboratory Medicine - Tập 131 Số 4 - Trang 625-636 - 2007
Ricardo Macarenco1,2,3, Fred Ellinger1,2,3, André M. Oliveira1,2,3
1From CIPAX-Medicina Diagnostica, Sao Jose dos Campos, SP, Brazil (Dr Macarenco); the Departamento de Patologia, Faculdade de Medicina de Marilia, Marilia, SP, Brazil (Dr Ellinger); and the Division of Anatomic Pathology, Mayo Clinic, Rochester, Minn (Dr Oliveira). Dr Macarenco is currently a visiting pathologist at the Division of Anatomic Pathology, Mayo Clinic, Rochester, Minn
2the Departamento de Patologia, Faculdade de Medicina de Marilia, Marilia, SP, Brazil (Dr Ellinger)
3the Division of Anatomic Pathology, Mayo Clinic, Rochester, Minn (Dr Oliveira). Dr Macarenco is currently a visiting pathologist at the Division of Anatomic Pathology, Mayo Clinic, Rochester, Minn

Tóm tắt

AbstractContext.—Perineuriomas are benign peripheral nerve sheath neoplasms composed of perineurial cells with characteristic immunohistochemical and ultrastructural features. They have been traditionally classified into two main types according to their location—intraneural and extraneural—and overlap histologically with many other tumors, which may be diagnostically challenging to general surgical pathologists.Objective.—To review the clinical, morphologic, immunohistochemical, ultrastructural, cytogenetic, and molecular genetic aspects of perineurioma, as well as to discuss its clinicopathologic variants and differential diagnosis.Data Sources.—English-language literature published between 1966 and 2005 was reviewed.Conclusions.—The correct identification of perineuriomas is important to avoid unnecessary overtreatment. The histologic diagnosis should be confirmed through immunohistochemical studies (including epithelial membrane antigen, S100 protein, and more recently described antibodies such as claudin-1 and GLUT1) or electron microscopy. Cytogenetic and molecular genetic studies are still of limited value for the diagnosis of perineuriomas but may play a fundamental role in excluding important differential diagnoses and also in helping elucidate the biology of these poorly known neoplasms.

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Archives of Pathology and Laboratory Medicine

Tập 131 Số 4

625-636

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