Pegylated, full-length, recombinant factor VIII for prophylactic and on-demand treatment of severe hemophilia A

Blood - Tập 126 Số 9 - Trang 1078-1085 - 2015
Barbara A. Konkle1, Oleksandra Stasyshyn2, Pratima Chowdary3, David Bevan4, Tim Mant5, Midori Shima6, Werner Engl7, Jacqueline Dyck-Jones8, Monika Fuerlinger7, Lisa Patrone8, Bruce M. Ewenstein8, Brigitt E. Abbuehl7
1Puget Sound Blood Center and University of Washington, Seattle, WA;
2Academy of Medical Sciences of Ukraine, Lviv, Ukraine
3Katharine Dormandy Haemophilia Centre and Thrombosis Unit, Royal Free Hospital, London, United Kingdom;
4St. Thomas' Hospital, London, United Kingdom
5Quintiles Drug Research Unit at Guy’s Hospital, London, United Kingdom
6Nara Medical University Hospital, Nara, Japan
7Baxalta Innovations GmbH, Vienna, Austria; and
8Baxalta US Inc., Westlake Village, CA

Tóm tắt

Key Points

BAX 855, a pegylated full-length rFVIII with extended half-life, was highly effective in the prevention and treatment of bleeding events. No subjects receiving BAX 855 developed FVIII inhibitory antibodies nor experienced unexpected adverse events.

Từ khóa


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